Evidence map›Paper›PMID 36978868›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Hyperoxia Disrupts Lung Lymphatic Homeostasis in Neonatal Mice.

Nithyapriya Shankar, Shyam Thapa, Amrit Kumar Shrestha, Poonam Sarkar, M Waleed Gaber, Roberto Barrios, Binoy Shivanna

Open access · goldFull text read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Oxidative Stress in Fetuses and Newborns.Antioxidants (Basel, Switzerland) · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nithyapriya ShankarDivision of Neonatology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
Shyam ThapaDivision of Neonatology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine (BCM), Houston, TX 77030, USA.ORCID 0000-0001-5040-1900
Amrit Kumar ShresthaDivision of Neonatology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
Poonam SarkarDivision of Hematology-Oncology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
M Waleed GaberDivision of Hematology-Oncology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
Roberto BarriosDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Binoy ShivannaDivision of Neonatology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine (BCM), Houston, TX 77030, USA.ORCID 0000-0001-8119-5783
Baylor College of Medicine · USMethodist Hospital · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Mechanistic Roles of Adrenomedullin and its Signaling Receptors in Experimental Bronchopulmonary Dysplasia and Pulmonary HypertensionR01HL139594 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI SHIVANNA, BINOY · 2018 to 2022
$2.0M
Regulatory T cells and Inflammatory Injury of the Developing Murine LungsR03HD103823 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI SHIVANNA, BINOY · 2021 to 2022
$160k
NHLBI NIH HHS R01 HL139594NICHD NIH HHS R03 HD103823NIDDK NIH HHS P30 DK056338NIH HHS HD103823NIH HHS HL139594NIH HHS P30DK056338
6 · The paper itself

Abstract

Inflammation causes bronchopulmonary dysplasia (BPD), a common lung disease of preterm infants. One reason this disease lacks specific therapies is the paucity of information on the mechanisms regulating inflammation in developing lungs. We address this gap by characterizing the lymphatic phenotype in an experimental BPD model because lymphatics are major regulators of immune homeostasis. We hypothesized that hyperoxia (HO), a major risk factor for experimental and human BPD, disrupts lymphatic endothelial homeostasis using neonatal mice and human dermal lymphatic endothelial cells (HDLECs). Exposure to 70% O

Indexed as

bronchopulmonary dysplasiahuman dermal lymphatic endothelial cellshyperoxialymphangiogenesislymphatic function

Identifiers

PMID36978868
PMCPMC10045755
OpenAlexW4323047262

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read42
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.