Evidence map›Paper›PMID 36978803›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Oxidative Stress and Cardiovascular Risk Factors: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Amir S Heravi, Di Zhao, Erin D Michos, Henrique Doria De Vasconcellos, Bharath Ambale-Venkatesh, Donald Lloyd-Jones, Pamela J Schreiner, Jared P Reis, James M Shikany, Cora E Lewis and 7 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Amir S HeraviSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Di ZhaoBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA.
Erin D MichosSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-5547-5084
Henrique Doria De VasconcellosSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-9758-2240
Bharath Ambale-VenkateshSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-2330-2373
Donald Lloyd-JonesFeinberg School of Medicine, Northwestern University, Chicago, IL 60208, USA.
Pamela J SchreinerSchool of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Jared P ReisNational Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
James M ShikanySchool of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Cora E LewisSchool of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-2301-5796
Chiadi E NdumeleSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Eliseo GuallarBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-4471-9565
Pamela OuyangSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-4925-9059
Ron C HoogeveenBaylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2399-4653
Joao A C LimaSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Wendy S PostSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Dhananjay VaidyaSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Johns Hopkins University · USUniversity of Alabama at Birmingham · USBaylor College of Medicine · USNational Heart Lung and Blood Institute · USNorthwestern University · USUniversity of Minnesota · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSISR01HL053560 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GROSS, MYRON D, JACOBS, DAVID R · 1995 to 2014
$9.0M
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS R01 HL053560NIDDK NIH HHS P30 DK079626NIH HHS 1RO1-HL53560-01A1
6 · The paper itself

Abstract

Introduction-Oxidative stress is linked to cardiovascular diseases (CVD) and is suggested to vary by sex. However, few population-level studies have explored these associations and the majority comprise populations with advanced CVD. We assessed urinary isoprostane concentrations, a standard measure of oxidative stress, in a relatively young and healthy cohort, hypothesizing that higher oxidative stress is associated with an adverse cardiometabolic profile and female sex. Methods-Oxidative stress was measured in 475 women and 266 men, aged 48-55 years, from the Coronary Artery Risk Development in Young Adults (CARDIA) study using urinary 8-isoprostane (IsoP) and 2,3-dinor-8-isoprostane (IsoP-M). Multivariable-adjusted regression was used to evaluate cross-sectional associations. As secondary analysis, previously measured plasma F2-isoprostanes (plasma IsoP) from another CARDIA subset was similarly analyzed. Results-Mean (SD) ages for men and women were 52.1(2.3) and 52.2(2.2) years, respectively (

Indexed as

2,3-dinor-8-isoprostane8-isoprostanecardiovascular disease risk factorsoxidative stressurinary isoprostanes

Identifiers

PMID36978803
PMCPMC10044794
OpenAlexW4321596767

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read15
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.