Evidence map›Paper›PMID 36978668›Full record

ArticleBioengineering (Basel, Switzerland)2023

Screening for Osteoporosis from Blood Test Data in Elderly Women Using a Machine Learning Approach.

Atsuyuki Inui, Hanako Nishimoto, Yutaka Mifune, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Ryosuke Kuroda

Open access · goldFull text read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Ensemble-learning approach improves fracture prediction using genomic and phenotypic data.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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  10. Featured Papers in Computer Methods in Biomedicine.Bioengineering (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Atsuyuki InuiDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.ORCID 0000-0002-0806-6579
Hanako NishimotoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.
Yutaka MifuneDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.
Tomoya YoshikawaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.ORCID 0000-0002-7613-5521
Issei ShinoharaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.ORCID 0000-0002-4122-7119
Takahiro FurukawaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.ORCID 0000-0002-1681-6974
Tatsuo KatoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.
Shuya TanakaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.ORCID 0000-0001-6349-5993
Masaya KusunoseDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.
Ryosuke KurodaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-5-1, Chuou-ku, Kobe City 650-0017, Japan.
Kobe University · JPKobe Rosai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of osteoporosis is made by measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA). Machine learning, one of the artificial intelligence methods, was used to predict low BMD without using DXA in elderly women. Medical records from 2541 females who visited the osteoporosis clinic were used in this study. As hyperparameters for machine learning, patient age, body mass index (BMI), and blood test data were used. As machine learning models, logistic regression, decision tree, random forest, gradient boosting trees, and lightGBM were used. Each model was trained to classify and predict low-BMD patients. The model performance was compared using a confusion matrix. The accuracy of each trained model was 0.772 in logistic regression, 0.739 in the decision tree, 0.775 in the random forest, 0.800 in gradient boosting, and 0.834 in lightGBM. The area under the curve (AUC) was 0.595 in the decision tree, 0.673 in logistic regression, 0.699 in the random forest, 0.840 in gradient boosting, and 0.961, which was the highest, in the lightGBM model. Important features were BMI, age, and the number of platelets. Shapley additive explanation scores in the lightGBM model showed that BMI, age, and ALT were ranked as important features. Among several machine learning models, the lightGBM model showed the best performance in the present research.

Indexed as

artificial intelligencemachine learningosteoporosis

Identifiers

PMID36978668
PMCPMC10045086
OpenAlexW4321500041

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read7
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.