Evidence map›Paper›PMID 36978486›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Computer-Aided Drug Design and Synthesis of Rhenium Clotrimazole Antimicrobial Agents.

Youri Cortat, Miroslava Nedyalkova, Kevin Schindler, Parth Kadakia, Gozde Demirci, Sara Nasiri Sovari, Aurelien Crochet, Stefan Salentinig, Marco Lattuada, Olimpia Mamula Steiner and 1 more

Open access · goldFull text read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Youri CortatDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.
Miroslava NedyalkovaDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.ORCID 0000-0003-0793-3340
Kevin SchindlerDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.ORCID 0000-0001-5487-2283
Parth KadakiaDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.
Gozde DemirciDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.ORCID 0000-0003-4952-7981
Sara Nasiri SovariDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.
Aurelien CrochetDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.ORCID 0000-0002-4763-2764
Stefan SalentinigDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.
Marco LattuadaDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.
Olimpia Mamula SteinerHaute école d'Ingénierie et d'Architecture, University of Applied Sciences Western Switzerland HES-SO, Pérolles 80, 1700 Fribourg, Switzerland.ORCID 0000-0002-3538-3553
Fabio ZobiDepartment of Chemistry, Fribourg University, Chemin Du Musée 9, 1700 Fribourg, Switzerland.ORCID 0000-0002-9077-7184
University of Fribourg · CHHES-SO University of Applied Sciences and Arts Western Switzerland · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the context of the global health issue caused by the growing occurrence of antimicrobial resistance (AMR), the need for novel antimicrobial agents is becoming alarming. Inorganic and organometallic complexes represent a relatively untapped source of antibiotics. Here, we report a computer-aided drug design (CADD) based on a 'scaffold-hopping' approach for the synthesis and antibacterial evaluation of

Indexed as

clotrimazoledockingrheniumStaphylococcus aureus MurG

Identifiers

PMID36978486
PMCPMC10044843
OpenAlexW4328123446

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read29
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.