Evidence map›Paper›PMID 36978449›Full record

ReviewAntibiotics (Basel, Switzerland)2023

Efficacy of Cefoperazone Sulbactam in Patients with

Gowthami Sai Kogilathota Jagirdhar, Kaanthi Rama, Shiva Teja Reddy, Harsha Pattnaik, Rakhtan K Qasba, Praveen Reddy Elmati, Rahul Kashyap, Marco Schito, Nitin Gupta

Full text readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gowthami Sai Kogilathota JagirdharDepartment of Medicine, Saint Michaels Medical Center, Newark, NJ 07104, USA.ORCID 0000-0003-1855-0863
Kaanthi RamaGandhi Medical College and Hospital, Secunderabad 500003, Telangana, India.
Shiva Teja ReddyGandhi Medical College and Hospital, Secunderabad 500003, Telangana, India.
Harsha PattnaikLady Hardinge Medical College, New Delhi 110001, India.
Rakhtan K QasbaGreen Life Medical College and Hospital, Dhaka 1205, Bangladesh.ORCID 0000-0001-5051-9319
Praveen Reddy ElmatiInterventional Pain Medicine, University of Louisville, Louisville, KY 40208, USA.
Rahul KashyapCritical Care Medicine, Department of Anesthesiology, Mayo Clinic, Rochester, MN 55092, USA.ORCID 0000-0002-4383-3411
Marco SchitoCURE Drug Repurposing Collaboratory (CDRC), Critical Path Institute, 1730 E River Rd, Tucson, AZ 85718, USA.ORCID 0000-0003-0113-4628
Nitin GuptaDepartment of Infectious Disease, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, India.ORCID 0000-0002-9687-2836

Funding

CURE Drug Repurposing Collaboratory NA
6 · The paper itself

Abstract

introduction

methodsWe conducted a systematic review of articles downloaded from Cochrane, Embase, PubMed, Scopus, and Web of Science (through June 2022) to study the efficacy of CS in treating AB infections. Our review evaluated patients treated with CS alone and CS in combination with other antibiotics separately. The following outcomes were studied: clinical cure, microbiological cure, and mortality from any cause.

resultsWe included 16 studies where CS was used for the treatment of AB infections. This included 11 studies where CS was used alone and 10 studies where CS was used in combination. The outcomes were similar in both groups. We found that the pooled clinical cure, microbiological cure, and mortality with CS alone for AB were 70%, 44%, and 20%, respectively. The pooled clinical cure, microbiological cure, and mortality when CS was used in combination with other antibiotics were 72%, 43%, and 21%, respectively.

conclusionsCS alone or in combination needs to be further explored for the treatment of AB infections. There is a need for randomized controlled trials with comparator drugs to evaluate the drug's effectiveness.

Indexed as

Acinetobacter baumanniiantimicrobial resistancemultidrug resistanceventilator-associated pneumonia

Identifiers

PMID36978449
PMCPMC10044834

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read21
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.