Evidence map›Paper›PMID 36978440›Full record

ArticleAntibiotics (Basel, Switzerland)2023

The Role of Procalcitonin as an Antimicrobial Stewardship Tool in Patients Hospitalized with Seasonal Influenza.

Ingrid Christensen, Dag Berild, Jørgen Vildershøj Bjørnholt, Lars-Petter Jelsness-Jørgensen, Sara Molvig Debes, Jon Birger Haug

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In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ingrid ChristensenØstfold Hospital Trust, Department of Infection Control, 1714 Kalnes, Norway.
Dag BerildInstitute of Clinical Medicine and Department of Infectious Diseases, Oslo University Hospital, 0450 Oslo, Norway.
Jørgen Vildershøj BjørnholtInstitute of Clinical Medicine, Faculty of Medicine, Oslo University, 0450 Oslo, Norway.
Lars-Petter Jelsness-JørgensenØstfold Hospital Trust, Department of Infection Control, 1714 Kalnes, Norway.
Sara Molvig DebesØstfold Hospital Trust, Center for Laboratory Medicine, 1714 Kalnes, Norway.ORCID 0000-0002-6342-2601
Jon Birger HaugØstfold Hospital Trust, Department of Infection Control, 1714 Kalnes, Norway.
Oslo University Hospital · NOØstfold Hospital Trust · NOØstfold University College · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUp to 60% of the antibiotics prescribed to patients hospitalized with seasonal influenza are unnecessary. Procalcitonin (PCT) has the potential as an antimicrobial stewardship program (ASP) tool because it can differentiate between viral and bacterial etiology. We aimed to explore the role of PCT as an ASP tool in hospitalized seasonal influenza patients.

methodsWe prospectively included 116 adults with seasonal influenza from two influenza seasons, 2018-2020. All data was obtained from a single clinical setting and analyzed by descriptive statistics and regression models.

resultsIn regression analyses, we found a positive association of PCT with 30 days mortality and the amount of antibiotics used. Influenza diagnosis was associated with less antibiotic use if the PCT value was low. Patients with a low initial PCT (<0.25 µg/L) had fewer hospital and intensive care unit (ICU) days and fewer positive chest X-rays. PCT had a negative predictive value of 94% for ICU care stay, 98% for 30 days mortality, and 88% for bacterial coinfection.

conclusionPCT can be a safe rule-out test for bacterial coinfection. Routine PCT use in seasonal influenza patients with an uncertain clinical picture, and rapid influenza PCR testing, may be efficient as ASP tools.

Indexed as

antimicrobial resistanceantimicrobial stewardshipdiagnostic toolhospitalprocalcitoninseasonal influenza

Identifiers

PMID36978440
PMCPMC10044820
OpenAlexW4324140908

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.