Evidence map›Paper›PMID 36978369›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Managing Patient and Clinician Expectations of Phage Therapy in the United Kingdom.

Joshua D Jones, Helen J Stacey, Arlene Brailey, Mehrunisha Suleman, Ross J Langley

Open access · goldFull text read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Predictive phage therapy forProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Joshua D JonesClinical Microbiology, Ninewells Hospital, NHS Tayside, Dundee DD2 1SG, UK.
Helen J StaceyPublic Health, Kings Cross Hospital, Clepington Road, Dundee DD3 8EA, UK.
Arlene BraileyAntibiotic Research UK, Genesis 5, York Science Park, Church Lane, Heslington, York YO10 5DQ, UK.
Mehrunisha SulemanThe Ethox Centre, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford OX3 7LF, UK.
Ross J LangleyDepartment of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, 1345 Govan Road, Glasgow G51 4TF, UK.
Antibiotic Research UK · GBKing's Cross Hospital · GBNHS Tayside · GBRoyal Hospital for Children · GBWellcome Centre for Ethics and Humanities · GB

Funding

Medical Research Council MC_PC_18046
6 · The paper itself

Abstract

Bacteriophage (phage) therapy is a promising alternative antimicrobial approach which has the potential to transform the way we treat bacterial infections. Phage therapy is currently being used on a compassionate basis in multiple countries. Therefore, if a patient has an antibiotic refractory infection, they may expect their clinician to consider and access phage therapy with the hope of improvement. The expectations of clinicians may be similar and may also include expectations around data collection. However, there are multiple biological and practical barriers to fulfilling patient and clinician expectations. While it is possible to access phage therapy, the path to acquisition is not straightforward and expectations therefore need to be managed appropriately to avoid raising false hope and undermining confidence in phage therapy. Phage scientists have an important contribution to make in educating clinicians and the broader public about phage therapy. However, it is clinicians that are responsible for managing the expectations of their patients and this relies on clear communication about the barriers and limitations.

Indexed as

bacteriophageethicsexpectationpatientphage therapyUnited Kingdom

Identifiers

PMID36978369
PMCPMC10044641
OpenAlexW4323043055

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.