Evidence map›Paper›PMID 36978196›Full record

ArticleBiomaterials research2023

A dual functional Ti-Ga alloy: inhibiting biofilm formation and osteoclastogenesis differentiation via disturbing iron metabolism.

Fupeng Li, Kai Huang, Jinbing Wang, Kai Yuan, Yiqi Yang, Yihao Liu, Xianhao Zhou, Keyu Kong, Tao Yang, Jian He and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Fupeng Li *Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Kai Huang *Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. kai_huang@aliyun.com.
Jinbing Wang *Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai, 200011, China.
Kai YuanDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yiqi YangDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yihao LiuDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Xianhao ZhouDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Keyu KongDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Tao YangDepartment of Materials Science and Engineering, Hong Kong Institute for Advanced Study, College of Science and Engineering, City University of Hong Kong, Hong Kong, China.
Jian HeM-Duke Medical Technology (Shanghai) Co., Ltd, Shanghai, Shanghai, China.
Chunjie LiuM-Duke Medical Technology (Shanghai) Co., Ltd, Shanghai, Shanghai, China.
Haiyong AoJiangxi Key Laboratory of Nanobiomaterials & School of Materials Science and Engineering, East China Jiaotong University, Nanchang, 330000, China.
Fengxiang LiuDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. liu_fengxiang@126.com.
Qian LiuDepartment of laboratory medicine, Ren Ji Hospital, Shanghai Jiao tong university school of medicine, Shanghai, 200127, China. liuqian_rj@shsmu.edu.cn.
Tingting TangDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. ttt@sjtu.edu.cn.
Shengbing YangDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. shengbingyang@shsmu.edu.cn.
Shanghai Jiao Tong University · CNShanghai Ninth People's Hospital · CNShanghai Medical College of Fudan University · CNCity University of Hong Kong · HKEast China Jiaotong University · CNRenji Hospital · CN

Funding

Cross-disciplinary Research Fund of Shanghai Ninth People's, Shanghai JiaoTong university School of Medicine JYJC202212Fundamental research program funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong university School of Medicine JYZZ200National Natural Science Foundation of China 32101092National Natural Science Foundation of China 82072235National Natural Science Foundation of China 82272509National Natural Science Foundation of China 92068205Natural Science Foundation of Jiangxi Province 20212ACB214002Ningxia Hui Autonomous Region's Key R&D Program for Foreign Scientific and Technological Cooperation Projects 2022BFH02010Science and Technology Innovation Action Plan of Shanghai Science and Technology Committee 22015820100Shanghai Sailing Program 20YF1422600Shanghai Science and Technology Development Fund 20QC1400800
6 · The paper itself

Abstract

backgroundAlthough biomedical implants have been widely used in orthopedic treatments, two major clinical challenges remain to be solved, one is the bacterial infection resulting in biofilm formation, and the other is aseptic loosening during implantation due to over-activated osteoclastogenesis. These factors can cause many clinical issues and even lead to implant failure. Thus, it is necessary to endow implants with antibiofilm and aseptic loosening-prevention properties, to facilitate the integration between implants and bone tissues for successful implantation. To achieve this goal, this study aimed to develop a biocompatible titanium alloy with antibiofilm and anti-aseptic loosening dual function by utilizing gallium (Ga) as a component.

methodsA series of Ti-Ga alloys were prepared. We examined the Ga content, Ga distribution, hardness, tensile strength, biocompatibility, and anti-biofilm performance in vitro and in vivo. We also explored how Ga

resultsThe alloy exhibited outstanding antibiofilm properties against both S. aureus and E. coli in vitro and decent antibiofilm performance against S. aureus in vivo. The proteomics results demonstrated that Ga

conclusionThis study provides an advanced Ti-Ga alloy that can be used as a promising orthopedic implant raw material for various clinical scenarios. This work also revealed that iron metabolism is the common target of Ga

Indexed as

Anti-biofilmBacterial adhesionImplant-associated infectionsTi-Ga alloy

Identifiers

PMID36978196
PMCPMC10053110
OpenAlexW4361215178

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.