Evidence map›Paper›PMID 36978093›Full record

ReviewJournal of nanobiotechnology2023

Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities.

Zhijie Xu, Yuzhen Xu, Kui Zhang, Yuanhong Liu, Qiuju Liang, Abhimanyu Thakur, Wei Liu, Yuanliang Yan

Full text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Nutrients · 2026
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  6. Bioactive materials · 2026
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhijie Xu *Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yuzhen Xu *Department of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, 271000, China.
Kui ZhangState Key Laboratory of Silkworm Genome Biology, Medical Research Institute, Southwest University, Chongqing, 400715, China.
Yuanhong LiuDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Qiuju LiangDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Abhimanyu ThakurPritzker School of Molecular Engineering, Ben May Department for Cancer Research, University of Chicago, Chicago, IL, 60637, USA.
Wei LiuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yuanliang YanDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. yanyuanliang@csu.edu.cn.

Funding

National Natural Science Foundation of China 82272659Science and Technology Program of Hunan Province 2021RC3029Science and Technology Program of Hunan Province 2022RC1210
6 · The paper itself

Abstract

backgroundThe past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using biochemical technologies, multiple independent groups have demonstrated the important roles of PDEVs as potential mediators involved in cell-cell communication and the exchange of bio-information between species. Recently, several contents have been well identified in PDEVs, including nucleic acids, proteins, lipids, and other active substances. These cargoes carried by PDEVs could be transferred into recipient cells and remarkably influence their biological behaviors associated with human diseases, such as cancers and inflammatory diseases. This review summarizes the latest updates regarding PDEVs and focuses on its important role in nanomedicine applications, as well as the potential of PDEVs as drug delivery strategies to develop diagnostic and therapeutic agents for the clinical management of diseases, especially like cancers.

conclusionConsidering its unique advantages, especially high stability, intrinsic bioactivity and easy absorption, further elaboration on molecular mechanisms and biological factors driving the function of PDEVs will provide new horizons for the treatment of human disease.

Indexed as

Extracellular VesiclesNeoplasmsCell CommunicationDrug Delivery SystemsHumansNanomedicineCancerCell-cell communicationHuman diseasesNanomedicinePlant-derived extracellular vesicles

Identifiers

PMID36978093
PMCPMC10049910

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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measurements read3
identifiers read8
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.