Evidence map›Paper›PMID 36978091›Full record

ArticleJournal of translational medicine2023

Identification of transcription factors related to diabetic tubulointerstitial injury.

Jialu Liu, Guangzhong Duan, Wenxia Yang, Shumin Zhang, Fuyou Liu, Youming Peng, Lin Sun, Yu Liu, Li Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jialu Liu *Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Guangzhong Duan *Hunan Communication Polytechnic, Changsha, 410132, Hunan, China.
Wenxia YangDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Shumin ZhangDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Fuyou LiuDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Youming PengDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Lin SunDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Yu LiuDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Li XiaoDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. xiaolizndx@csu.edu.cn.ORCID 0000-0002-5488-5583
Central South University · CNHunan Communications Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic nephropathy (DN) is a main cause of chronic renal failure. Despite decades of extensive study, the molecular mechanisms underlying diabetic tubulointerstitial injury remain unclear. We aim to identify key transcription factor genes involved in diabetic tubulointerstitial injury.

methodsA microarray dataset (GSE30122) from Gene Expression Omnibus (GEO) was downloaded. A total of 38 transcription factor genes based on 166 differentially expressed genes (DEGs) were identified by UCSC_TFBS.

resultsThe regulatory network showed connections between the top 10 transcription factors and their target DEGs. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of targeted DEGs indicated that extracellular space, extracellular exosome, cell surface and complement and coagulation cascades were most significantly enriched. Utilizing Nephroseq v5 online platform, the mRNA expression pattern analysis of transcription factor genes demonstrated that mRNA expression of CDC5, CEBPA, FAC1, HFH1, IRF1, NFE2 and TGIF1 increased in renal tubulointerstitium of DN patients compared with normal controls while that of CEBPB and FOXO4 decreased in renal tubulointerstitium of DN patients compared with normal controls. Correlation analysis between mRNA expression of transcription factor genes in renal tubulointerstitium and clinical features showed that AP1, BACH1, CDC5, FAC1, FOXD1, FOXJ2, FOXO1, FOXO4, HFH1, IRF1, POU3F2, SOX5, SOX9, RSRFC4, S8 and TGIF1 may be related to diabetic tubulointerstitial injury.

conclusions(1) CDC5, FAC1, FOXO4, HFH1, IRF1 and TGIF1 may be key transcription factor genes. (2)Transcription factors involved in diabetic tubulointerstitial injury may become prospective targets for diagnosis and treatment of DN.

Indexed as

Diabetes MellitusDiabetic NephropathiesComputational BiologyForkhead Transcription FactorsGene Expression ProfilingGene Regulatory NetworksHomeodomain ProteinsHumansMicroarray AnalysisRepressor ProteinsRNA, MessengerTranscription FactorsForkhead Transcription FactorsFOXD1 protein, humanFOXJ2 protein, humanHomeodomain ProteinsRepressor ProteinsRNA, MessengerTGIF1 protein, humanTranscription FactorsComputational biologyDiabetic nephropathiesRegulatory networkTranscription factorTubulointerstitial injury

Identifiers

PMID36978091
PMCPMC10053902
OpenAlexW4361284693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.