Evidence map›Paper›PMID 36977968›Full record

ArticleActa diabetologica2023

The use of isCGM leads to marked reduction in severe hypoglycemia requiring emergency medical service or hospital admission and diabetic ketoacidosis in adult type 1 diabetes patients.

Jyrki Mustonen, Päivi Rautiainen, Marja-Leena Lamidi, Piia Lavikainen, Janne Martikainen, Tiina Laatikainen

Abstract read
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Article in Acta diabetologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jyrki MustonenDepartment of Internal Medicine, Joint Municipal Authority for North Karelia Social and Health Services (Siun Sote), Tikkamäentie 16, 80210, Joensuu, Finland. jyrki.mustonen@siunsote.fi.ORCID http://orcid.org/0000-0002-1400-5983
Päivi RautiainenDepartment of Internal Medicine, Joint Municipal Authority for North Karelia Social and Health Services (Siun Sote), Tikkamäentie 16, 80210, Joensuu, Finland.
Marja-Leena LamidiInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.
Piia LavikainenSchool of Pharmacy, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.
Janne MartikainenSchool of Pharmacy, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.
Tiina LaatikainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.

Funding

Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding project QCAREStrategic Research Council 312703Strategic Research Council 336325
6 · The paper itself

Abstract

aimsTo determine the effect of the use of intermittently scanned continuous glucose monitoring (isCGM) on acute diabetes-related complications in adult type 1 diabetes patients.

methodsSix hundred and forty-two adult type 1 diabetes patients with isCGM were identified from electronic health records in Siun sote region in Eastern Finland. A retrospective real-world analysis was conducted combining hospital admission and prehospital emergency service data to compare incidences of hypoglycemia requiring emergency medical support (EMS) involvement or hospital admission and diabetic ketoacidosis (DKA) before and after the start of isCGM. Data were collected from January 2015 to April 2020. Primary outcome was the rate of hypoglycemia requiring EMS involvement or hospital admission and DKA events. HbA1c was recorded at the start of isCGM and was compared with the last known HbA1c during the use of isCGM. The isCGM used in the study did not contain alarm functions.

resultsAltogether 220 hypoglycemic events were identified during the study period. Incidence rate of hypoglycemic events decreased after the start of isCGM (72 events, incidence rate 50 events/1000 person-years) compared with the time before the start (148 events, incidence rate 76 events/1000 person-years) (p = 0.043). The incidence rate of DKA decreased after the start of isCGM compared with time before isCGM use (4 and 15 events/1000 person-years, respectively; p = 0.002). The change in mean HbA1c was - 0.28% (- 3.1 mmol/mol) between baseline and the last HbA1c measurement (p < 0.001).

conclusionsIn addition to lowering HbA1c in type 1 diabetes patients, isCGM is also effective in preventing acute diabetes-related complications such as hypoglycemia requiring EMS involvement or hospital admission and DKA.

Indexed as

Diabetes Mellitus, Type 1Diabetic KetoacidosisEmergency Medical ServicesHypoglycemiaAdultBlood GlucoseBlood Glucose Self-MonitoringGlycated HemoglobinHospitalsHumansHypoglycemic AgentsRetrospective StudiesBlood GlucoseGlycated HemoglobinHypoglycemic AgentsDiabetic ketoacidosisGlucose monitorHypoglycemiaisCGMType 1 diabetes

Identifiers

PMID36977968
PMCPMC10198841

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.