Evidence map›Paper›PMID 36977963›Full record

ArticleNeurocritical care2023

Ethics Along the Continuum of Research Involving Persons with Disorders of Consciousness.

Ariane Lewis, Michael J Young, Benjamin Rohaut, Ralf J Jox, Jan Claassen, Claire J Creutzfeldt, Judy Illes, Matthew Kirschen, Stephen Trevick, Joseph J Fins and 1 more

Abstract read
In one paragraph

Article in Neurocritical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Covert brain complexity in the intensive care unit.Cortex; a journal devoted to the study of the nervous system and behavior · 2026
    Article
  3. Article
  4. Review
  5. Ethical Considerations in Transcranial Focused Ultrasound Neuromodulation for Disorders of Consciousness.Neuromodulation : journal of the International Neuromodulation Society · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Disorders of Consciousness Rehabilitation: Ethical Dimensions and Epistemic Dilemmas.Physical medicine and rehabilitation clinics of North America · 2024
    Review
  12. Covert consciousness.NeuroRehabilitation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ariane LewisNYU Langone Medical Center, 530 First Avenue, Skirball-7R, New York, NY, 10016, USA. ariane.kansas.lewis@gmail.com.ORCID 0000-0002-0756-7320
Michael J YoungMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin RohautInserm, CNRS, APHP - Hôpital de la Pitié Salpêtrière, Paris Brain Institute - ICM, DMU Neuroscience, Sorbonne University, Paris, France.
Ralf J JoxLausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Jan ClaassenNew York Presbyterian Hospital, Columbia University, New York, NY, USA.
Claire J CreutzfeldtHarborview Medical Center, Seattle, WA, USA.
Judy IllesUniversity of British Columbia, Vancouver, BC, Canada.
Matthew KirschenThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Stephen TrevickNorthwest Neurology, Chicago, IL, USA.
Joseph J FinsWeill Cornell Medical College, New York, NY, USA.
The Curing Coma Campaign and its Contributing Members

Funding

Central thalamic stimulation for traumatic brain injuryUH3NS095554 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTSON, CHRISTOPHER R, GIACINO, JOSEPH THOMAS · 2015 to 2021
$6.9M
RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGeR01NS106014 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2023
$3.6M
Cerebral autoregulation and MRI measures of brain injury after pediatric-post cardiac arrestK23NS116120 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI KIRSCHEN, MATTHEW P · 2021 to 2025
$966k
Cognitive Restoration: Neuroethics and Disability RightsRF1MH121378 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI FINS, JOSEPH J. · 2019 to 2019
$858k
An Ethical Approach to Detecting Covert ConsciousnessF32MH123001 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI YOUNG, MICHAEL J · 2020 to 2022
$159k
NIMH NIH HHS F32 MH123001NIMH NIH HHS RF1 MH121378NINDS NIH HHS K23 NS116120NINDS NIH HHS R01 NS106014NINDS NIH HHS UH3 NS095554
6 · The paper itself

Abstract

Interest in disorders of consciousness (DoC) has grown substantially over the past decade and has illuminated the importance of improving understanding of DoC biology; care needs (use of monitoring, performance of interventions, and provision of emotional support); treatment options to promote recovery; and outcome prediction. Exploration of these topics requires awareness of numerous ethics considerations related to rights and resources. The Curing Coma Campaign Ethics Working Group used its expertise in neurocritical care, neuropalliative care, neuroethics, neuroscience, philosophy, and research to formulate an informal review of ethics considerations along the continuum of research involving persons with DoC related to the following: (1) study design; (2) comparison of risks versus benefits; (3) selection of inclusion and exclusion criteria; (4) screening, recruitment, and enrollment; (5) consent; (6) data protection; (7) disclosure of results to surrogates and/or legally authorized representatives; (8) translation of research into practice; (9) identification and management of conflicts of interest; (10) equity and resource availability; and (11) inclusion of minors with DoC in research. Awareness of these ethics considerations when planning and performing research involving persons with DoC will ensure that the participant rights are respected while maximizing the impact and meaningfulness of the research, interpretation of outcomes, and communication of results.

Indexed as

ComaConsciousness DisordersCommunicationConsciousnessHumansPrognosisComaDisorders of consciousnessEthicsResearch

Identifiers

PMID36977963
PMCPMC11023737

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.