ArticleClinical oral investigations2023
Biocompatibility analysis in subcutaneous tissue and physico-chemical analysis of pre-mixed calcium silicate-based sealers.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Comparison of push-out bond strength and Si QScientific reports · 2026Article
- Immunomodulatory and pro-mineralizing effects of an injectable baicalein-loaded methacrylated gelatin hydrogel for vital pulp therapy.Biomaterials advances · 2026Article
- Effect of Root Canal Drying Methods on Bioceramic Sealer Bond Strength.Acta stomatologica Croatica · 2026Article
- Effect of the Blooming Artifact Reduction filter on the detection of voids in root canal fillings using cone-beam computed tomography images.Brazilian dental journal · 2026Article
- Comparison of Chemico-Physical Properties and Calcium Ion Release of Bioceramic Root Canal Sealers: A PilotJournal of pharmacy & bioallied sciences · 2025Article
- Enhancing image quality: The role of low-radiopacity bioceramic materials in CBCT scans.Imaging science in dentistry · 2025Article
- Could the sealer thickness affect the filling ability of bioceramic endodontic materials? Evaluation in a simulated physiological condition.Journal of conservative dentistry and endodontics · 2025Article
- Physicochemical properties and biological interaction of calcium silicate-based sealers - in vivo model.Clinical oral investigations · 2025Article
- Influence of Bioceramic Clinker particle size, radiopacifier, and liquids on their physicochemical properties.Brazilian dental journal · 2025Article
- Physicochemical and antibiofilm properties of new ready-to-use and powder/gel bioceramic endodontic sealers.Brazilian oral research · 2025Article
- Oxidative damage analysis and cell viability of Drosophila melanogaster exposed to three different endodontic sealers: an in vivo and ex vivo study.Odontology · 2024Article
- Biological properties versus solubility of endodontic sealers and cements.Biomaterial investigations in dentistry · 2024Review
- Filling ability of ready-to-use or powder-liquid calcium silicate-based sealers after ultrasonic agitation.Brazilian dental journal · 2024Article
- Influence of bioceramic cones on the quality of root canal filling relative to bond strength and adaptation of the adhesive interface.Clinical oral investigations · 2023Article
- Growth Factors Released from Advanced Platelet-Rich Fibrin in the Presence of Calcium-Based Silicate Materials and Their Impact on the Viability and Migration of Stem Cells of Apical Papilla.Dentistry journal · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the biocompatibility, physical and chemical properties of three pre-mixed calcium silicate-based sealers and an epoxy resin-based material were assessed. Pre-mixed sealers supposedly obtain water from the root canal moist to hydrate and set. MATERIALS AND
methodsPolyethylene tubes were filled with the materials Bio-C Sealer Ion+, Bio-C Sealer, EndoSequence BC Sealer and AH Plus Jet, or left empty and surgically implanted in the subcutaneous tissue of Wistar rats. The animals were euthanised and the tubes and tissue were removed for histological analysis and scanning electron microscopy (SEM) coupled with energy-dispersive spectrometry (EDS). Materials' surface chemical characterisation was assessed using Raman spectroscopy and SEM/EDS. Flow, setting time (in two conditions), solubility, radiopacity and pH were also analysed. ANOVA and Bonferroni correction were performed for comparisons (P < 0.05).
resultsInflammatory response observed in the tissues subsided from 7 to 30 days. Tungsten migration could be detected in the surrounding tissue following AH Plus Jet implantation. All calcium silicate-based sealers exhibited zirconium oxide (radiopacifier) and tricalcium silicate peaks before and after implantation. All materials exhibited flow values above 17 mm. An approximately tenfold difference was observed between the plaster- and metal-mould setting times of the calcium silicate cements indicating its sensitivity to moist variations and solubility above 8% was also observed for these materials.
conclusionsPre-mixed materials exhibited variable setting time and solubility with a decreasing inflammatory response. CLINICAL RELEVANCE: The variable moist-dependant setting time with high solubility poses a concern for the clinical use of these pre-mixed sealers.
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