Evidence map›Paper›PMID 36977683›Full record

ArticleNPJ microgravity2023

Optimizing transcranial magnetic stimulation for spaceflight applications.

S M Romanella, L Mencarelli, K Seyedmadani, S Jillings, E Tomilovskaya, I Rukavishnikov, G Sprugnoli, S Rossi, F L Wuyts, E Santarnecchi

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

S M RomanellaPrecision Neuroscience and Neuromodulation Program, Gordon Center for Medical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. sromanella@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7202-5421
L MencarelliNon-invasive Brain Stimulation Unit, IRCSS "Santa Lucia" Foundation, Rome, Italy.
K SeyedmadaniBiomedical Engineering Department, University of Houston, NASA Johnson Space Center Houston, Houston, TX, USA.
S JillingsLab for Equilibrium Investigations and Aerospace (LEIA), University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-7298-8925
E TomilovskayaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0002-9030-6876
I RukavishnikovInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
G SprugnoliSiena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Siena, Italy.
S RossiSiena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Siena, Italy.
F L WuytsLab for Equilibrium Investigations and Aerospace (LEIA), University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-4485-6412
E SantarnecchiPrecision Neuroscience and Neuromodulation Program, Gordon Center for Medical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. esantarnecchi@mgh.harvard.edu.
Harvard University · USInstitute of Biomedical Problems · RUUniversity of Antwerp · BEUniversity of Siena · ITFondazione Santa Lucia · ITJohnson Space Center · US

Funding

Gamma Induction for Amyloid Clearance in Alzheimer’s DiseaseR01AG060981 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SANTARNECCHI, EMILIANO · 2019 to 2023
$3.5M
European Space Agency (ESA) Grant ISLRA 2009-1062Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01 AG060981-01NIA NIH HHS R01 AG060981
6 · The paper itself

Abstract

As space agencies aim to reach and build installations on Mars, the crews will face longer exposure to extreme environments that may compromise their health and performance. Transcranial magnetic stimulation (TMS) is a painless non-invasive brain stimulation technique that could support space exploration in multiple ways. However, changes in brain morphology previously observed after long-term space missions may impact the efficacy of this intervention. We investigated how to optimize TMS for spaceflight-associated brain changes. Magnetic resonance imaging T1-weighted scans were collected from 15 Roscosmos cosmonauts and 14 non-flyer participants before, after 6 months on the International Space Station, and at a 7-month follow-up. Using biophysical modeling, we show that TMS generates different modeled responses in specific brain regions after spaceflight in cosmonauts compared to the control group. Differences are related to spaceflight-induced structural brain changes, such as those impacting cerebrospinal fluid volume and distribution. We suggest solutions to individualize TMS to enhance its efficacy and precision for potential applications in long-duration space missions.

Identifiers

PMID36977683
PMCPMC10050431
OpenAlexW4361214040

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read10
table measurements read6
reference markers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.