ArticleTranslational psychiatry2023
Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Oxytocin preserves excitatory responsiveness of VTA dopaminergic neurons in PTSD model rats.IBRO neuroscience reports · 2026Article
- Altered amygdala and striatal responsivity and prediction error encoding of temporal reward dynamics in post-trauma psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts.Psychological medicine · 2026Article
- Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Anhedonia and PTSD symptom severity profiles differentially influence physical activity volume in trauma-exposed adults.European journal of psychotraumatology · 2025Article
- Physical activity moderates the relationship between PTSD symptom severity and approach-avoidance conflict decision-making.Journal of anxiety disorders · 2025Article
- Physical Activity Is Positively Associated with Model-Based Decision-Making in Pursuit of Reward in Trauma-Exposed Adults.Medicine and science in sports and exercise · 2025Article
- Climate trauma from wildfire exposure impacts cognitive decision-making.Scientific reports · 2025Article
- Choosing certainty over risk: Associations of PTSD symptom severity with memory sampling during experiential decision making.Journal of anxiety disorders · 2025Article
- Amygdala Structure and Function: Association With Transdiagnostic Trauma Severity in Anxiety and Mood Disorder Patients.Psychophysiology · 2025Article
- Moderate stability of risk and ambiguity attitudes across quantitative and qualitative decisions.Scientific reports · 2025Article
- Representation of Anticipated Rewards and Punishments in the Human Brain.Annual review of psychology · 2025Review
- Quantitative vs. Qualitative Outcomes: A Longitudinal Study of Risk and Ambiguity in Monetary and Medical Decision-Making.Research square · 2024Article
- Latent-state and model-based learning in PTSD.Trends in neurosciences · 2024Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is associated with changes in fear learning and decision-making, suggesting involvement of the brain's valuation system. Here we investigate the neural mechanisms of subjective valuation of rewards and punishments in combat veterans. In a functional MRI study, male combat veterans with a wide range of posttrauma symptoms (N = 48, Clinician Administered PTSD Scale, CAPS-IV) made a series of choices between sure and uncertain monetary gains and losses. Activity in the ventromedial prefrontal cortex (vmPFC) during valuation of uncertain options was associated with PTSD symptoms, an effect which was consistent for gains and losses, and specifically driven by numbing symptoms. In an exploratory analysis, computational modeling of choice behavior was used to estimate the subjective value of each option. The neural encoding of subjective value varied as a function of symptoms. Most notably, veterans with PTSD exhibited enhanced representations of the saliency of gains and losses in the neural valuation system, especially in ventral striatum. These results suggest a link between the valuation system and the development and maintenance of PTSD, and demonstrate the significance of studying reward and punishment processing within subject.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.