ArticleJornal de pediatria
Prediction of coronary artery lesions based on C-reactive protein levels in children with Kawasaki Disease: a retrospective cohort study.
Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Single Nucleotide Polymorphisms and Their Association with Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease in Ireland.Pediatric cardiology · 2026Article
- A clinical-biomarker fusion model for risk prediction of coronary artery lesions in Kawasaki disease.Italian journal of pediatrics · 2026Article
- Novel biomarker-based prediction model for coronary artery lesions in Kawasaki disease.BMC pediatrics · 2026Article
- The correlation and auxiliary diagnostic value of gut microbiota and serological indicators with Kawasaki disease complicated by coronary artery lesions.Frontiers in cellular and infection microbiology · 2026Article
- Long-term impaired exercise capacity and oxygen consumption in Kawasaki disease patients.European journal of pediatrics · 2025Article
- Correlation between peripheral blood Th17/Treg immune imbalance and coronary artery lesions in children with Kawasaki disease.BMC immunology · 2025Article
- A retrospective cohort study using machine learning to predict coronary artery lesions in children with Kawasaki disease.BMC pediatrics · 2025Article
- Clinical value of combined detection of serum ferritin and N-terminal pro-brain natriuretic peptide in the assessment of Kawasaki disease in children over 1 year of age.Italian journal of pediatrics · 2025Article
- Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females.Paediatrics & child health · 2025Article
- Immunophenotype of Kawasaki Disease: Insights into Pathogenesis and Treatment Response.Life (Basel, Switzerland) · 2025Review
- Risk factors associated with persistent coronary artery lesions in children with Kawasaki disease in an Italian cohort.European journal of pediatrics · 2025Article
- Development and validation of an explainable machine learning-based prediction model for primary Kawasaki disease complicated with coronary artery aneurysms.Translational pediatrics · 2025Article
- Impact of intravenous immunoglobulin treatment on peripheral blood cells in children with Kawasaki disease complicated with coronary artery lesion.Italian journal of pediatrics · 2025Article
- A risk stratification model for coronary artery lesions in Kawasaki disease: focus on subgroup-specific utility.Frontiers in cardiovascular medicine · 2025Article
- A universal model for predicting coronary artery lesions in subgroups of kawasaki disease in China: based on cluster analysis.Frontiers in cardiovascular medicine · 2025Article
- Expression of Serum Ferritin, Human neutrophil lipocalin, Procalcitonin, and inflammatory factors in children with Kawasaki disease and their relationship to coronary artery lesions.American journal of translational research · 2025Article
- Clinical & laboratory profiles and treatment outcome of Kawasaki disease in children: Experience from a tertiary care hospital.PloS one · 2025Article
- Risk Factors and Regression of Coronary Aneurysms in Infants With Kawasaki Disease.Cardiovascular therapeutics · 2025Article
- The role of serum lipid in predicting coronary artery lesions and intravenous immunoglobulin resistance in Kawasaki disease: a cohort study.The Journal of international medical research · 2024Article
- Expression of Oxidative Stress and Inflammatory Indicators for Coronary Artery Disease in Kawasaki Disease.Mediterranean journal of hematology and infectious diseases · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSince coronary artery lesions (CALs) are the most severe complication of Kawasaki disease (KD), clinically speaking, early prediction of CALs is crucial. The authors aimed to investigate the predictive value of C-reactive protein (CRP) in predicting CALs in KD patients.
methodsKD patients were divided into the CALs group and the non-CALs group. The clinical and laboratory parameters were collected and compared. Multivariate logistic regression analysis was used to determine the independent risk factors of CALs. The receiver operating characteristic curve was applied to determine the optimal cut-off value.
results851 KD patients who met the inclusion criteria were studied, including 206 in the CALs group and 645 in the non-CALs group. Children in the CALs group had significantly higher CRP levels than the non-CALs group (p < 0.05). Multivariable logistic regression analysis showed that incomplete KD, male, lower hemoglobin, and higher CRP were independent risk factors for predicting CAL (all p < 0.05). The optimal cut-off value of initial serum CRP for predicting CALs was 105.5 mg/L, with a sensitivity of 47.57% and a specificity of 69.61%. In addition, KD patients with high CRP (≥105.5 mg/L) had a higher occurrence of CALs than those with low CRP (<105.5 mg/L) (33% vs 19%, p < 0.001).
conclusionThe incidence of CALs was significantly higher in patients with high CRP. CRP is an independent risk factor for CALs formation and may be useful for predicting CALs in KD patients.
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