Evidence map›Paper›PMID 36977413›Full record

ReviewMolecular cell2023

Ferroptosis: A flexible constellation of related biochemical mechanisms.

Scott J Dixon, Derek A Pratt

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
50.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 190 citations in OpenAlex.

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  17. Dissecting Complex Interactions Between Ferroptosis and the Proteasome.bioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Scott J DixonDepartment of Biology, Stanford University, Stanford, CA, USA. Electronic address: sjdixon@stanford.edu.
Derek A PrattDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada. Electronic address: dpratt@uottawa.ca.
Stanford Medicine · USUniversity of Ottawa · CA

Funding

Characterizing the Regulation of FerroptosisR01GM122923 · NIGMS · STANFORD UNIVERSITY · PI Scott Dixon · 2017 to 2026
$3.4M
NIGMS NIH HHS R01 GM122923
6 · The paper itself

Abstract

It is common to think about and depict biological processes as being governed by fixed pathways with specific components interconnected by concrete positive and negative interactions. However, these models may fail to effectively capture the regulation of cell biological processes that are driven by chemical mechanisms that do not rely absolutely on specific metabolites or proteins. Here, we discuss how ferroptosis, a non-apoptotic cell death mechanism with emerging links to disease, may be best understood as a highly flexible mechanism that can be executed and regulated by many functionally related metabolites and proteins. The inherent plasticity of ferroptosis has implications for how to define and study this mechanism in healthy and diseased cells and organisms.

Indexed as

FerroptosisCell DeathIronLipid PeroxidationPhospholipid Hydroperoxide Glutathione PeroxidaseIronPhospholipid Hydroperoxide Glutathione Peroxidasecell deathferroptosisironlipidpathwayperoxidationPUFAROS

Identifiers

PMID36977413
PMCPMC10081971
OpenAlexW4361002012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.