Evidence map›Paper›PMID 36977081›Full record

ArticleToxins2023

The Effectiveness of Antibiotics in Managing Bacterial Infections on Bite Sites following Snakebite Envenomation.

Subramanian Senthilkumaran, Anika Salim, José R Almeida, Jarred Williams, Pradeep Vijayakumar, Angayarkanni Thirunavukarasu, Markellos Alexandros Christopoulos, Harry F Williams, Ponniah Thirumalaikolundusubramanian, Ketan Patel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Subramanian SenthilkumaranManian Medical Centre, Erode 638001, Tamil Nadu, India.ORCID 0000-0001-5262-8367
Anika SalimSchool of Pharmacy, University of Reading, Reading RG6 6UB, UK.
José R AlmeidaSchool of Pharmacy, University of Reading, Reading RG6 6UB, UK.ORCID 0000-0002-4637-4468
Jarred WilliamsSchool of Pharmacy, University of Reading, Reading RG6 6UB, UK.
Pradeep VijayakumarSchool of Pharmacy, University of Reading, Reading RG6 6UB, UK.ORCID 0000-0002-9894-2201
Angayarkanni ThirunavukarasuManian Medical Centre, Erode 638001, Tamil Nadu, India.
Markellos Alexandros ChristopoulosSchool of Pharmacy, University of Reading, Reading RG6 6UB, UK.
Harry F WilliamsToxiven Biotech Private Limited, Coimbatore 641042, Tamil Nadu, India.ORCID 0000-0001-5095-3131
Ponniah ThirumalaikolundusubramanianThe Tamil Nadu Dr M.G.R Medical University, Chennai 600032, Tamil Nadu, India.ORCID 0000-0003-1814-8743
Ketan PatelSchool of Biological Sciences, University of Reading, Reading RG6 6UB, UK.
Sakthivel VaiyapuriSchool of Pharmacy, University of Reading, Reading RG6 6UB, UK.ORCID 0000-0002-6006-6517
University of Reading · GBPeriyar Maniammai Institute of Science & Technology · INTamil Nadu Dr. M.G.R. Medical University · IN

Funding

Medical Research Council MR/W019353/1
6 · The paper itself

Abstract

Snakebite envenomation (SBE) is a life-threatening medical emergency with a high mortality rate. Common secondary complications following SBE, such as wound infections, are significant due to their impact on worsening local tissue damage and causing systemic infection. Antivenoms are not effective to treat wound infections following SBE. Moreover, in several rural clinical settings, broad-spectrum antibiotics are often used without clear guidelines or based on limited laboratory data, resulting in undesirable side effects and exacerbated treatment costs. Therefore, robust antibiotic strategies should be developed to tackle this critical issue. Currently, there is limited information available on the bacterial profiles of SBE-induced infections and antibiotic susceptibility. Hence, it is essential to improve the knowledge of bacterial profiles and their antibiotic sensitivity in SBE victims to develop better treatment strategies. This study aimed to address this issue by examining the bacterial profiles of SBE victims with a specific focus on Russell's viper envenomation. The most frequently found bacteria in the bites of SBE victims were

Indexed as

Bacterial InfectionsSnake BitesAnti-Bacterial AgentsAntiveninsHumansViper VenomsAnti-Bacterial AgentsAntiveninsViper Venomsantibiotic resistanceantibioticsantibiotic sensitivityDaboia russeliiRussell’s vipersnakebite envenomationwound infections

Identifiers

PMID36977081
PMCPMC10057039
OpenAlexW4323044154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.