Evidence map›Paper›PMID 36977061›Full record

SynthesisToxins2023

Investigation of Best Practices for Venom Toxin Purification in Jellyfish towards Functional Characterisation.

Blake Lausen, Anahita Ahang, Scott Cummins, Tianfang Wang

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Blake LausenCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs 4556, Australia.
Anahita AhangCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs 4556, Australia.
Scott CumminsCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs 4556, Australia.ORCID 0000-0002-1454-2076
Tianfang WangCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs 4556, Australia.
University of the Sunshine Coast · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relative lack of marine venom pharmaceuticals can be anecdotally attributed to difficulties in working with venomous marine animals, including how to maintain venom bioactivity during extraction and purification. The primary aim of this systematic literature review was to examine the key factors for consideration when extracting and purifying jellyfish venom toxins to maximise their effectiveness in bioassays towards the characterisation of a single toxin.An up-to-date database of 119 peer-reviewed research articles was established for all purified and semi-purified venoms across all jellyfish, including their level of purification, LD50, and the types of experimental toxicity bioassay used (e.g., whole animal and cell lines). We report that, of the toxins successfully purified across all jellyfish, the class Cubozoa (i.e.,

Indexed as

Cnidarian VenomsCubozoaScyphozoaAnimalsCell LineChromatography, GelCnidarian Venomsbioassaybiodiscoveryextractionjellyfishmedusozoapurificationtoxinsvenom

Identifiers

PMID36977061
PMCPMC10059823
OpenAlexW4321498377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.