ArticlePLoS pathogens2023
Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus.
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Article in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Evaluation of a Zika virus-like particle-based vaccine in a highly penetrant non-human primate model of congenital infection.PLoS neglected tropical diseases · 2026Article
- A Zika Virus-Like Particle Vaccine Mitigates Early Pregnancy Loss In Rhesus Macaques.bioRxiv : the preprint server for biology · 2025Article
- Inside-out: modelling the link between Zika virus viral dynamics within hosts and transmission to vectors across host species and virus strains.Journal of the Royal Society, Interface · 2025Article
- Oropouche virus efficiently replicates and is immunostimulatory in vivo in nonhuman primate species.Science advances · 2025Article
- Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.The Lancet. Microbe · 2025Review
- Article
- Macaque Models of Prenatal and Postnatal Zika Virus Exposure and Developmental Outcomes.Journal of the Pediatric Infectious Diseases Society · 2025Review
- Pathological characterization of female reproductive organs prior to miscarriage induced by Zika virus infection in the pregnant common marmoset.Microbiology spectrum · 2025Article
- Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques.Frontiers in immunology · 2025Article
- Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity.Nature communications · 2024Article
- Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.Signal transduction and targeted therapy · 2024Review
- Chronic innate immune impairment and ZIKV persistence in the gastrointestinal tract during SIV infection in pigtail macaques.bioRxiv : the preprint server for biology · 2024Article
- The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation.PLoS neglected tropical diseases · 2024Article
- Replication properties of a contemporary Zika virus from West Africa.PLoS neglected tropical diseases · 2024Article
- Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model.PLoS pathogens · 2023Article
- Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques.Science advances · 2023Article
- Comparative Infections of Zika, Dengue, and Yellow Fever Viruses in Human Cytotrophoblast-Derived Cells Suggest a Gating Role for the Cytotrophoblast in Zika Virus Placental Invasion.Microbiology spectrum · 2023Article
- Control of maternal Zika virus infection during pregnancy is associated with lower antibody titers in a macaque model.Frontiers in immunology · 2023Article
- Article
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Authors and funding
40 authors at 5 institutions in 1 country.
Jenna R RosinskiDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.ORCID 0000-0003-3709-2132
Lauren E RaaschDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Patrick Barros TiburcioDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Meghan E BreitbachDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Phoenix M ShepherdDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Keisuke YamamotoDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Elaina RazoDepartment of Pediatrics, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Nicholas P KrabbeDepartment of Pediatrics, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Mason I BlissWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Alexander D RichardsonWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Morgan A EinwalterWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Andrea M WeilerWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Emily L SneedWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Kerri B FuchsWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Xiankun ZengUnited States Army Medical Research Institute of Infectious Diseases; Fort Detrick, Maryland, Unites States of America.
Kevin K NoguchiDepartment of Psychiatry, Washington University School of Medicine; St. Louis, Washington, Unites States of America.
Terry K MorganDepartment of Pathology, Oregon Health and Science University; Portland, Oregon, Unites States of America.
Alexandra J AlbertsDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Kathleen M AntonyDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Sabrina KabakovDepartment of Kinesiology, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Karla K AusderauDepartment of Kinesiology, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Ellie K BohmDepartment of Veterinary and Biomedical Science, University of Minnesota; St. Paul, Minnesota, Unites States of America.
Julia C PritchardDepartment of Veterinary and Biomedical Science, University of Minnesota; St. Paul, Minnesota, Unites States of America.
Rachel V SpantonDepartment of Kinesiology, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
James N Ver HooveDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Charlene B Y KimDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
T Michael NorkDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Alex W KatzDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Carol A RasmussenDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Amy HartmanDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Andres MejiaWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Puja BasuWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Jens C EickhoffDepartment of Biostatistics & Medical Informatics, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Thomas C FriedrichDepartment of Pathobiological Sciences, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Matthew T AliotaDepartment of Veterinary and Biomedical Science, University of Minnesota; St. Paul, Minnesota, Unites States of America.
Emma L MohrDepartment of Pediatrics, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Dawn M DudleyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
David H O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Christina M NewmanDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
University of Wisconsin–Madison · USUniversity of Minnesota · USOregon Health & Science University · USUnited States Army Medical Research Institute of Infectious Diseases · USWashington University in St. Louis · US
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MWUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5MUW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6MZika virus pathophysiology during pregnancyP01AI132132 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$10.2MEarly neural predictors and neuropathogenesis of sensorimotor neurodevelopmental deficits in macaque infants exposed to Zika virus in uteroR01AI153130 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI AUSDERAU, KARLA KAYE, MOHR, EMMA L · 2020 to 2024
$3.8MAssessing the impact of acquired immunodeficiency on congenital Zika virusR01AI138647 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$3.8MDefining maternal and neonatal antibody responses in congenital Zika virus infectionK08AI139341 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MOHR, EMMA L · 2019 to 2023
$1.0MNEI NIH HHS P30 EY016665NIAID NIH HHS K08 AI139341NIAID NIH HHS P01 AI132132NIAID NIH HHS R01 AI138647NIAID NIH HHS R01 AI153130NICHD NIH HHS P50 HD103525NIH HHS P51 OD011106
Abstract
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.
Indexed as
Abortion, SpontaneousPregnancy Complications, InfectiousSimian Immunodeficiency VirusZika VirusZika Virus InfectionAnimalsFemaleHumansMacaca mulattaPregnancyPregnancy Trimester, First
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