Evidence map›Paper›PMID 36976794›Full record

SynthesisPLoS medicine2023

Prevalence and natural history of depression after stroke: A systematic review and meta-analysis of observational studies.

Lu Liu, Min Xu, Iain J Marshall, Charles DA Wolfe, Yanzhong Wang, Matthew Dl O'Connell

Open access · goldFull text readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 14 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 14 syntheses or guidelines pooled it, 159 citations in OpenAlex.

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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lu LiuSchool of Life Course and Population Sciences, King's College London, London, United Kingdom.ORCID 0000-0001-5521-7766
Min XuSchool of Life Course and Population Sciences, King's College London, London, United Kingdom.
Iain J MarshallSchool of Life Course and Population Sciences, King's College London, London, United Kingdom.
Charles DA WolfeSchool of Life Course and Population Sciences, King's College London, London, United Kingdom.ORCID 0000-0001-8264-0981
Yanzhong WangSchool of Life Course and Population Sciences, King's College London, London, United Kingdom.ORCID 0000-0002-0768-1676
Matthew Dl O'ConnellSchool of Life Course and Population Sciences, King's College London, London, United Kingdom.
King's College London · GB

Funding

Department of Health NIHR202339
6 · The paper itself

Abstract

backgroundDepression is the most frequent psychiatric condition after stroke and is associated with negative health outcomes. We aim to undertake a systematic review and meta-analysis of the prevalence and natural history of depression after stroke. METHODS AND

findingsStudies published up to 4 November 2022 on Medline, Embase, PsycINFO, and Web of Science Core Collection were searched. We included studies of adults with stroke, where depression was assessed at a prespecified time point. Studies excluding people with aphasia and history of depression are excluded. Critical Appraisal Skills Programme(CASP) cohort study tool was used to assess risk of bias. A total of 77 studies were included in the pooled estimates of the prevalence of poststroke depression (PSD). The overall prevalence of depression was 27% (95% CI 25 to 30). Prevalence of depression was 24% (95% CI 21 to 28) by clinical interview and 29% (95% CI 25 to 32) by rating scales. Twenty-four studies with more than one assessment time point reported the natural history of PSD. Among people who were depressed within 3 months of stroke, 53% (95% CI 47 to 59) experienced persistent depression, while 44% (95% CI 38 to 50) recovered. The incidence of later depression (3 to 12 months after stroke) was 9% (95% CI 7 to 12). The cumulative incidence during 1 year after stroke was 38% (95% CI 33 to 43), and the majority (71% (95% CI 65 to 76)) of depression had onset within 3 months after stroke. The main limitation of the present study is that excluding people in source studies with severe impairments may produce imprecise estimates of the prevalence of PSD.

conclusionsIn this study, we observed that stroke survivors with early-onset depression (within 3 months after stroke) are at high risks for remaining depressed and make up two-thirds of the incident cases during 1 year after stroke. This highlights the need for ongoing clinical monitoring of patients depressed shortly after stroke.

trial registrationPROSPERO CRD42022314146.

Indexed as

DepressionStrokeAdultCohort StudiesHumansLongitudinal StudiesPrevalence

Identifiers

PMID36976794
PMCPMC10047522
OpenAlexW4361215288

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read75
identifiers read7
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.