Evidence map›Paper›PMID 36976771›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA.

Jason C Bell, Christopher C Dombrowski, Jody L Plank, Ryan B Jensen, Stephen C Kowalczykowski

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jason C BellDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA 95616.
Christopher C DombrowskiDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA 95616.
Jody L PlankDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA 95616.
Ryan B JensenDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA 95616.
Stephen C KowalczykowskiDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA 95616.ORCID 0000-0002-9127-3949
University of California, Davis · USYale University · US

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Single-molecule Visualization and Mechanisms of DNA Recombination and Intersecting DNA TransactionsR35GM131900 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Stephen Charles Kowalczykowski · 2019 to 2026
$6.6M
Mechanistic Studies of Genetic RecombinationR01GM062653 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KOWALCZYKOWSKI, STEPHEN CHARLES · 2010 to 2018
$4.4M
Single-Molecule Assembly of Protein-DNA ComplexesR01GM064745 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI KOWALCZYKOWSKI, STEPHEN CHARLES · 2002 to 2018
$4.3M
MECHANISTIC STUDIES OF GENETIC RECOMBINATIONR37GM062653 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI KOWALCZYKOWSKI, STEPHEN CHARLES · 2000 to 2009
$3.6M
Molecular Functions of Recombination in Genome Stability and Tumor SuppressionR01CA208600 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KOWALCZYKOWSKI, STEPHEN CHARLES · 2017 to 2021
$1.8M
Mismatch Repair and the Fidelity Enforcement of Homologous RecombinationF32CA136103 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PLANK, JODY L. · 2008 to 2009
$76k
HHS | NIH | National Cancer Institute (NCI) CA10052159HHS | NIH | National Cancer Institute (NCI) CA136103HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM62653HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM64745NCI NIH HHS F32 CA136103NCI NIH HHS R01 CA208600NIGMS NIH HHS R01 GM062653NIGMS NIH HHS R01 GM064745NIGMS NIH HHS R35 GM131900NIGMS NIH HHS R37 GM062653NIGMS NIH HHS T32 GM007377
6 · The paper itself

Abstract

Mutations in the breast cancer susceptibility gene,

Indexed as

DNA, Single-StrandedReplication Protein ABRCA2 ProteinDNAGenes, BRCA2Homologous RecombinationHumansProtein BindingRad51 RecombinaseBRCA2 ProteinBRCA2 protein, humanDNADNA, Single-StrandedRAD51 protein, humanRad51 RecombinaseReplication Protein ARPA1 protein, humanbreast cancerDNA recombinationDNA repairRAD51single-molecule visualization

Identifiers

PMID36976771
PMCPMC10083600
OpenAlexW4361219120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.