Evidence map›Paper›PMID 36976450›Full record

ReviewBiological trace element research2024

Review of Zinc Oxide Nanoparticles: Toxicokinetics, Tissue Distribution for Various Exposure Routes, Toxicological Effects, Toxicity Mechanism in Mammals, and an Approach for Toxicity Reduction.

Junko Fujihara, Naoki Nishimoto

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 76 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Zinc oxide-bacteriophage synergistic combination for dual-mode antibacterial activity against multidrug-resistant Escherichia coli.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  6. Green synthesis of ZnO/FeRSC advances · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Long-term exposure to PMScientific reports · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Junko FujiharaDepartment of Legal Medicine, Shimane University Faculty of Medicine, 89-1 Enya, Izumo , Shimane, 693-8501, Japan. jfujihar@med.shimane-u.ac.jp.ORCID http://orcid.org/0000-0001-5359-5181
Naoki NishimotoDepartment of Research Planning and Coordination, Shimane Institute for Industrial Technology, 1 Hokuryo, Matsue, Shimane, 690-0816, Japan.ORCID http://orcid.org/0000-0002-5854-7848
Shimane Institute for Industrial Technology · JPShimane University · JP

Funding

Japan Society for the Promotion of Science 21H03212
6 · The paper itself

Abstract

Zinc oxide (ZnO) nanoparticles (NPs) are widely used as a sunscreen, antibacterial agent, dietary supplement, food additive, and semiconductor material. This review summarizes the biological fate following various exposure routes, toxicological effects, and toxicity mechanism of ZnO NPs in mammals. Furthermore, an approach to reduce the toxicity and biomedical applications of ZnO NPs are discussed. ZnO NPs are mainly absorbed as Zn

Indexed as

NanoparticlesZinc OxideAnimalsMammalsReactive Oxygen SpeciesTissue DistributionToxicokineticsReactive Oxygen SpeciesZinc OxideBiomedical applicationsReactive oxygen speciesTissue distributionToxicological effectsToxicological mechanismZinc oxide nanoparticles

Identifiers

PMID36976450
OpenAlexW4361191172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.