Evidence map›Paper›PMID 36976430›Full record

SynthesisNeuroinformatics2023

A Minimum Bayes Factor Based Threshold for Activation Likelihood Estimation.

Tommaso Costa, Donato Liloia, Franco Cauda, Peter T Fox, Francesca Dalla Mutta, Sergio Duca, Jordi Manuello

Abstract readMeta-Analysis
In one paragraph

Synthesis in Neuroinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tommaso CostaGCS-fMRI Group, Koelliker Hospital and Department of Psychology, University of Turin, Turin, Italy.
Donato LiloiaGCS-fMRI Group, Koelliker Hospital and Department of Psychology, University of Turin, Turin, Italy. donato.liloia@unito.it.
Franco CaudaGCS-fMRI Group, Koelliker Hospital and Department of Psychology, University of Turin, Turin, Italy.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Francesca Dalla MuttaFOCUS Laboratory, Department of Psychology, University of Turin, Via Verdi 10, 10124, Turin, Italy.
Sergio DucaGCS-fMRI Group, Koelliker Hospital and Department of Psychology, University of Turin, Turin, Italy.
Jordi ManuelloGCS-fMRI Group, Koelliker Hospital and Department of Psychology, University of Turin, Turin, Italy.

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
NIA NIH HHS P30 AG066546NIMH NIH HHS R01 MH074457
6 · The paper itself

Abstract

Activation likelihood estimation (ALE) is among the most used algorithms to perform neuroimaging meta-analysis. Since its first implementation, several thresholding procedures had been proposed, all referred to the frequentist framework, returning a rejection criterion for the null hypothesis according to the critical p-value selected. However, this is not informative in terms of probabilities of the validity of the hypotheses. Here, we describe an innovative thresholding procedure based on the concept of minimum Bayes factor (mBF). The use of the Bayesian framework allows to consider different levels of probability, each of these being equally significant. In order to simplify the translation between the common ALE practice and the proposed approach, we analised six task-fMRI/VBM datasets and determined the mBF values equivalent to the currently recommended frequentist thresholds based on Family Wise Error (FWE). Sensitivity and robustness toward spurious findings were also analyzed. Results showed that the cutoff log

Indexed as

BrainBrain MappingBayes TheoremHumansLikelihood FunctionsNeuroimagingActivation likelihood estimationBrainMapCoordinate-based meta-analysisGingerALEMinimum Bayes Factor

Identifiers

PMID36976430
PMCPMC10085951

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.