Evidence map›Paper›PMID 36976337›Full record

ArticleEuropean radiology2023

Improving lesion conspicuity in abdominal dual-energy CT with deep learning image reconstruction: a prospective study with five readers.

Jingyu Zhong, Lingyun Wang, Hailin Shen, Jianying Li, Wei Lu, Xiaomeng Shi, Yue Xing, Yangfan Hu, Xiang Ge, Defang Ding and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jingyu ZhongDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Lingyun WangDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hailin ShenDepartment of Radiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, 215028, China.
Jianying LiComputed Tomography Research Center, GE Healthcare, Beijing, 100176, China.
Wei LuComputed Tomography Research Center, GE Healthcare, Shanghai, 201203, China.
Xiaomeng ShiDepartment of Materials, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
Yue XingDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Yangfan HuDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Xiang GeDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Defang DingDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Fuhua YanDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Lianjun DuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. 13601745690@163.com.
Weiwu YaoDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. yaoweiwuhuan@163.com.ORCID http://orcid.org/0000-0002-6612-8520
Huan ZhangDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. huanzhangy@163.com.

Funding

Medicine and Engineering Combination Project of Shanghai Jiao Tong University YG2019ZDB09National Natural Science Foundation of China 82101986National Natural Science Foundation of China 82271934Research Fund of Tongren Hospital, Shanghai Jiao Tong University School of Medicine 2020TRYJ(JC)07Research Fund of Tongren Hospital, Shanghai Jiao Tong University School of Medicine 2020TRYJ(LB)06Research Fund of Tongren Hospital, Shanghai Jiao Tong University School of Medicine TRGG202101Research Fund of Tongren Hospital, Shanghai Jiao Tong University School of Medicine TRKYRC-XX202204Research Fund of Tongren Hospital, Shanghai Jiao Tong University School of Medicine TRYJ2021JC06Shanghai Science and Technology Commission Science and Technology Innovation Action Clinical Innovation Field 18411953000Yangfan Project of Science and Technology Commission of Shanghai Municipality 20YF1427200Yangfan Project of Science and Technology Commission of Shanghai Municipality 22YF1442400
6 · The paper itself

Abstract

objectivesTo evaluate image quality, diagnostic acceptability, and lesion conspicuity in abdominal dual-energy CT (DECT) using deep learning image reconstruction (DLIR) compared to those using adaptive statistical iterative reconstruction-V (Asir-V) at 50% blending (AV-50), and to identify potential factors impacting lesion conspicuity.

methodsThe portal-venous phase scans in abdominal DECT of 47 participants with 84 lesions were prospectively included. The raw data were reconstructed to virtual monoenergetic image (VMI) at 50 keV using filtered back-projection (FBP), AV-50, and DLIR at low (DLIR-L), medium (DLIR-M), and high strength (DLIR-H). A noise power spectrum (NPS) was generated. CT number and standard deviation values of eight anatomical sites were measured. Signal-to-noise (SNR), and contrast-to-noise ratio (CNR) values were calculated. Five radiologists assessed image quality in terms of image contrast, image noise, image sharpness, artificial sensation, and diagnostic acceptability, and evaluated the lesion conspicuity.

resultsDLIR further reduced image noise (p < 0.001) compared to AV-50 while better preserved the average NPS frequency (p < 0.001). DLIR maintained CT number values (p > 0.99) and improved SNR and CNR values compared to AV-50 (p < 0.001). DLIR-H and DLIR-M showed higher ratings in all image quality analyses than AV-50 (p < 0.001). DLIR-H provided significantly better lesion conspicuity than AV-50 and DLIR-M regardless of lesion size, relative CT attenuation to surrounding tissue, or clinical purpose (p < 0.05).

conclusionsDLIR-H could be safely recommended for routine low-keV VMI reconstruction in daily contrast-enhanced abdominal DECT to improve image quality, diagnostic acceptability, and lesion conspicuity. KEY POINTS: • DLIR is superior to AV-50 in noise reduction, with less shifts of the average spatial frequency of NPS towards low frequency, and larger improvements of NPS noise, noise peak, SNR, and CNR values. • DLIR-M and DLIR-H generate better image quality in terms of image contrast, noise, sharpness, artificial sensation, and diagnostic acceptability than AV-50, while DLIR-H provides better lesion conspicuity than AV-50 and DLIR-M. • DLIR-H could be safely recommended as a new standard for routine low-keV VMI reconstruction in contrast-enhanced abdominal DECT to provide better lesion conspicuity and better image quality than the standard AV-50.

Indexed as

Deep LearningAlgorithmsHumansImage Processing, Computer-AssistedProspective StudiesRadiation DosageRadiographic Image Interpretation, Computer-AssistedTomography, X-Ray ComputedDeep learningImage enhancementImage reconstructionMultidetector computed tomography

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.