Evidence map›Paper›PMID 36976245›Full record

ArticleMarine drugs2023

Tetrodotoxin Decreases the Contractility of Mesenteric Arteries, Revealing the Contribution of Voltage-Gated Na

Joohee Park, Coralyne Proux, William Ehanno, Léa Réthoré, Emilie Vessières, Jennifer Bourreau, Julie Favre, Gilles Kauffenstein, César Mattei, Hélène Tricoire-Leignel and 3 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. 6-Nitrodopamine Potentiates Catecholamine-Induced CaBasic & clinical pharmacology & toxicology · 2026
    Article
  2. A Novel Function of NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Joohee ParkINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0003-3903-8383
Coralyne ProuxINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.
William EhannoINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.
Léa RéthoréINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0001-7143-5966
Emilie VessièresINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.
Jennifer BourreauINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.
Julie FavreINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0003-1044-0950
Gilles KauffensteinINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0003-4994-8305
César MatteiINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0002-2214-2611
Hélène Tricoire-LeignelINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0002-2881-2962
Daniel HenrionINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0003-1094-0285
Claire LegendreINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0003-0248-1111
Christian LegrosINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, University Angers, 49000 Angers, France.ORCID 0000-0002-3346-7059
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrodotoxin (TTX) poisoning through the consumption of contaminated fish leads to lethal symptoms, including severe hypotension. This TTX-induced hypotension is likely due to the downfall of peripheral arterial resistance through direct or indirect effects on adrenergic signaling. TTX is a high-affinity blocker of voltage-gated Na

Indexed as

AortaMesenteric ArteriesAnimalsMammalsMiceTetrodotoxinVoltage-Gated Sodium Channel beta-1 SubunitScn1b protein, mouseTetrodotoxinVoltage-Gated Sodium Channel beta-1 Subunitaortamesenteric arteriesRT-qPCRTTXveratridinevoltage-gated Na+ channels

Identifiers

PMID36976245
PMCPMC10059581
OpenAlexW4360618950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.