Evidence map›Paper›PMID 36976205›Full record

ArticleMarine drugs2023

Mechanisms of Antitumor Invasion and Metastasis of the Marine Fungal Derivative Epi-Aszonalenin A in HT1080 Cells.

Yi Liu, Liyuan Lin, Haiyan Zheng, Yuan-Lin He, Yanmei Li, Chunxia Zhou, Pengzhi Hong, Shengli Sun, Yi Zhang, Zhong-Ji Qian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Exploring the Anti-Alzheimer's Disease Potential ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yi LiuSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Liyuan LinSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Haiyan ZhengSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Yuan-Lin HeSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Yanmei LiSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Chunxia ZhouSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.ORCID 0000-0001-7454-8384
Pengzhi HongSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Shengli SunSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Yi ZhangSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.ORCID 0000-0002-1600-7456
Zhong-Ji QianSchool of Chemistry and Environment, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.ORCID 0000-0001-9220-2600
Guangdong Ocean University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epi-aszonalenin A (EAA) is an alkaloid that is isolated and purified from the secondary metabolites of coral symbiotic fungi and has been shown to have good atherosclerotic intervention activity and anti-angiogenic activity in our previous studies. In the present study, antiangiogenic activity was used as a basis of an intensive study of its mechanism of action against tumor metastasis and invasion. Invasive metastatic pairs are a hallmark of malignancy, and the dissemination of tumor cells is the most dangerous process in the development of tumors. The results of cell wound healing and the Transwell chamber assay showed that EAA interfered well with PMA-induced migration and invasion of HT1080 cells. Western blot and the ELISA assay showed that EAA decreased MMPs and vascular endothelial growth factor (VEGF) activity and inhibited the expression of N-cadherin and hypoxia-inducible factor-1α (HIF-1α) by regulating the phosphorylation of downstream mitogen-activated protein kinase (MAPK), PI3K/AKT, and NF-κB pathways. Simultaneous molecular docking results revealed that the mimic coupling between the EAA and MMP-2/-9 molecules formed a stable interaction. The results of this study provide a research basis for the inhibition of tumor metastasis by EAA, and together with previous studies, confirm the potential pharmacology and drug potential for this class of compound for application in angiogenesis-related diseases and further improve the availability of coral symbiotic fungi.

Indexed as

Phosphatidylinositol 3-KinasesVascular Endothelial Growth Factor ACell Line, TumorCell MovementHypoxia-Inducible Factor 1, alpha SubunitIndole AlkaloidsMolecular Docking SimulationaszonaleninHypoxia-Inducible Factor 1, alpha SubunitIndole AlkaloidsPhosphatidylinositol 3-KinasesVascular Endothelial Growth Factor Aalkaloidscell signalingmatrix metalloproteinasesneoplasm metastasis

Identifiers

PMID36976205
PMCPMC10056024
OpenAlexW4322503175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.