Evidence map›Paper›PMID 36976202›Full record

ReviewMarine drugs2023

Structures and Anti-Allergic Activities of Natural Products from Marine Organisms.

Na Chen, Shanshan Zhang, Ansar Javeed, Cuiqin Jian, Yi Liu, Jinlyu Sun, Shandong Wu, Peng Fu, Bingnan Han

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. The Potential of Algae in the Nutricosmetic Sector.Molecules (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Na ChenZhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Shanshan ZhangZhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Ansar JaveedZhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.ORCID 0000-0003-4124-0273
Cuiqin JianZhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Yi LiuHangzhou Zheda Dixun Biological Gene Engineering Co., Ltd., Hangzhou 310018, China.
Jinlyu SunDepartment of Allergy, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Shandong WuHangzhou Zheda Dixun Biological Gene Engineering Co., Ltd., Hangzhou 310018, China.
Peng FuKey Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0000-0002-7768-4004
Bingnan HanZhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.ORCID 0000-0003-3616-9409
Zhejiang Sci-Tech University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNOcean University of China · CN

Funding

Key Laboratory Open Fund of Zhejiang Mariculture Research Institute No. Z2021001Key R&D Program of Zhejiang No. 2022C03055the Key Research and Development Program of Zhejiang Province, China No. 2021C02062This study was supported by the National Natural Science Foundation of China No. 81973233Zhejiang Sci-Tech University and Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd Anti-Allergy Functional Molecular Laboratory Cooperation Agreement No. 21040692-J
6 · The paper itself

Abstract

In recent years, allergic diseases have occurred frequently, affecting more than 20% of the global population. The current first-line treatment of anti-allergic drugs mainly includes topical corticosteroids, as well as adjuvant treatment of antihistamine drugs, which have adverse side effects and drug resistance after long-term use. Therefore, it is essential to find alternative anti-allergic agents from natural products. High pressure, low temperature, and low/lack of light lead to highly functionalized and diverse functional natural products in the marine environment. This review summarizes the information on anti-allergic secondary metabolites with a variety of chemical structures such as polyphenols, alkaloids, terpenoids, steroids, and peptides, obtained mainly from fungi, bacteria, macroalgae, sponges, mollusks, and fish. Molecular docking simulation is applied by MOE to further reveal the potential mechanism for some representative marine anti-allergic natural products to target the H1 receptor. This review may not only provide insight into information about the structures and anti-allergic activities of natural products from marine organisms but also provides a valuable reference for marine natural products with immunomodulatory activities.

Indexed as

Anti-Allergic AgentsBiological ProductsAnimalsAquatic OrganismsFungiMolecular Docking SimulationAnti-Allergic AgentsBiological Productsanti-allergicmarine organismsmolecular dockingsecondary metabolites

Identifiers

PMID36976202
PMCPMC10056057
OpenAlexW4322501390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.