Evidence map›Paper›PMID 36976069›Full record

ArticleJournal of functional biomaterials2023

Characterization of Cyclic Olefin Copolymers for Insulin Reservoir in an Artificial Pancreas.

Norma Mallegni, Mario Milazzo, Caterina Cristallini, Niccoletta Barbani, Giulia Fredi, Andrea Dorigato, Patrizia Cinelli, Serena Danti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Norma MallegniDepartment of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino, 56126 Pisa, Italy.
Mario MilazzoDepartment of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino, 56126 Pisa, Italy.ORCID 0000-0001-8429-5544
Caterina CristalliniNational Interuniversity Consortium for Materials Science and Technology (INSTM), Via Giuseppe Giusti 9, 50121 Florence, Italy.
Niccoletta BarbaniDepartment of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino, 56126 Pisa, Italy.
Giulia FrediNational Interuniversity Consortium for Materials Science and Technology (INSTM), Via Giuseppe Giusti 9, 50121 Florence, Italy.ORCID 0000-0001-9987-1786
Andrea DorigatoNational Interuniversity Consortium for Materials Science and Technology (INSTM), Via Giuseppe Giusti 9, 50121 Florence, Italy.
Patrizia CinelliDepartment of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino, 56126 Pisa, Italy.ORCID 0000-0003-2401-133X
Serena DantiDepartment of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino, 56126 Pisa, Italy.ORCID 0000-0002-8155-8537
University of Pisa · ITUniversity of Trento · ITInstitute for Chemical and Physical Processes · IT

Funding

Regione Toscana (Italy) Bando PAR FAS 2007-2013 - Azione 1.1.2; BANDO FAS SALUTE 2014), Robo-Implant Project (CUP J82F17000050005)
6 · The paper itself

Abstract

Type-1 diabetes is one of the most prevalent metabolic disorders worldwide. It results in a significant lack of insulin production by the pancreas and the ensuing hyperglycemia, which needs to be regulated through a tailored administration of insulin throughout the day. Recent studies have shown great advancements in developing an implantable artificial pancreas. However, some improvements are still required, including the optimal biomaterials and technologies to produce the implantable insulin reservoir. Here, we discuss the employment of two types of cyclic olefin copolymers (Topas 5013L-10 and Topas 8007S-04) for an insulin reservoir fabrication. After a preliminary thermomechanical analysis, Topas 8007S-04 was selected as the best material to fabricate a 3D-printed insulin reservoir due to its higher strength and lower glass transition temperature (T

Indexed as

3D-printingadditive manufacturingdiabetesinsulin aggregationmechanical characterizationsurface roughnessthermal characterizationTopas

Identifiers

PMID36976069
PMCPMC10053537
OpenAlexW4323315380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.