Evidence map›Paper›PMID 36975998›Full record

ArticleJournal of clinical microbiology2023

Development and Validation of TaqMan Chemistry Probe-Based Rapid Assay for the Detection of Echinocandin-Resistance in Candida auris.

YanChun Zhu, Kelli M Hager, Swati R Manjari, Nilesh K Banavali, Vishnu Chaturvedi, Sudha Chaturvedi

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. First Case of Bloodstream Infection byAnnals of laboratory medicine · 2026
    Article
  4. Review
  5. Frontiers in cellular and infection microbiology · 2026
    Review
  6. Article
  7. A benchmark dataset for validatingMicrobiology spectrum · 2025
    Article
  8. The multidrug-resistantCurrent research in microbial sciences · 2025
    Review
  9. What makesAntimicrobial agents and chemotherapy · 2024
    Article
  10. A simple and sensitive test forJournal of clinical microbiology · 2024
    Article
  11. Current issues in molecular biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

YanChun Zhu *Mycology Laboratory, Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Kelli M Hager *Mycology Laboratory, Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Swati R ManjariDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Nilesh K BanavaliDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Vishnu ChaturvediWestchester Medical Center, New York Medical College, Valhalla, New York, USA.ORCID 0000-0002-3922-9676
Sudha ChaturvediMycology Laboratory, Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0003-0906-8426
New York State Department of Health · USWestchester Medical Center · US

Funding

Glycomics-driven diagnostics for Candida aurisR21AI156573 · NIAID · RENSSELAER POLYTECHNIC INSTITUTE · PI CHATURVEDI, VISHNU, ZHANG, FUMING · 2021 to 2022
$454k
NCEZID CDC HHS U50 CK000423NIAID NIH HHS R21 AI156573
6 · The paper itself

Abstract

Candida auris is a multidrug-resistant yeast pathogen causing outbreaks in health care facilities worldwide, and the emergence of echinocandin-resistant C. auris is a concern. Currently used Clinical and Laboratory Standards Institute (CLSI) and commercial antifungal susceptibility tests (AFST) are phenotype-based, slow, and not scalable, limiting their effectiveness in the surveillance of echinocandin-resistant C. auris. The urgent need for accurate and rapid methods of assessment of echinocandin resistance cannot be overstated, as this class of antifungal drugs is preferred for patient management. We report the development and validation of a TaqMan chemistry probe-based fluorescence melt curve analysis (FMCA) following asymmetric polymerase chain reaction (PCR) to assess mutations within the hot spot one (HS1) region of

Indexed as

Antifungal AgentsCandida aurisDrug Resistance, Multiple, FungalEchinocandinsFungal ProteinsGlucosyltransferasesReal-Time Polymerase Chain ReactionCandidiasis, InvasiveDNA Mutational AnalysisFluorescenceMolecular ProbesMutationNucleic Acid DenaturationProtein Conformation, alpha-HelicalAntifungal AgentsEchinocandinsFks1 protein, Candida aurisFungal ProteinsGlucosyltransferasesMolecular ProbesantifungalsCandida aurisechinocandins resistancemolecular methods

Identifiers

PMID36975998
PMCPMC10117040
OpenAlexW4361190559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.