Evidence map›Paper›PMID 36975863›Full record

ReviewJournal of cardiovascular development and disease2023

Left-Sided Heart Defects and Laterality Disturbance in Hypoplastic Left Heart Syndrome.

Hisato Yagi, Cecilia W Lo

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. RNA binding proteins in cardiovascular development and disease.Current topics in developmental biology · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hisato YagiDepartment of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15201, USA.ORCID 0000-0003-1460-4043
Cecilia W LoDepartment of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15201, USA.ORCID 0000-0003-4314-3434
University of Pittsburgh · US

Funding

Modeling the genetic basis for human congenital heart disease in miceU01HL098180 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2009 to 2014
$8.5M
Modeling the complex genetics of congenital heart disease in miceR01HL132024 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2016 to 2019
$3.4M
Assaying Heterotaxy Patient Genes in Cilia Motility and Left-Right PatterningR01GM104412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENNUBHOTLA, SRINIVAS CHAKRA, LO, CECILIA W. · 2014 to 2017
$2.4M
American Heart Association 847524National Heart Lung and Blood Institute R01-HL132024National Heart Lung and Blood Institute U01-HL098180NIGMS NIH HHS R01-GM104412
6 · The paper itself

Abstract

Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized by hypoplasia of left-sided heart structures. The developmental basis for restriction of defects to the left side of the heart in HLHS remains unexplained. The observed clinical co-occurrence of rare organ situs defects such as biliary atresia, gut malrotation, or heterotaxy with HLHS would suggest possible laterality disturbance. Consistent with this, pathogenic variants in genes regulating left-right patterning have been observed in HLHS patients. Additionally,

Indexed as

heterotaxyhypoplastic left heart syndromelateralityleft–right patterningSin3A

Identifiers

PMID36975863
PMCPMC10054755
OpenAlexW4321790443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.