Evidence map›Paper›PMID 36975800›Full record

ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

Predictive Utility of Irritability "In Context": Proof-of-Principle for an Early Childhood Mental Health Risk Calculator.

Lauren S Wakschlag, Leigha A MacNeill, Lindsay R Pool, Justin D Smith, Hubert Adam, Deanna M Barch, Elizabeth S Norton, Cynthia E Rogers, Isaac Ahuvia, Christopher D Smyser and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lauren S WakschlagDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
Leigha A MacNeillDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
Lindsay R PoolDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine.
Justin D SmithDepartment of Population Health Sciences, Spencer Fox Eccles School of Medicine at University of Utah.
Hubert AdamDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
Deanna M BarchDepartment of Psychological and Brain Sciences, Washington University in St. Louis.
Elizabeth S NortonDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
Cynthia E RogersDepartment of Psychiatry, Washington University School of Medicine.
Isaac AhuviaDepartment of Clinical Psychology, Stony Brook University.
Christopher D SmyserMallinckrodt Institute of Radiology, Washington University School of Medicine.
Joan L LubyDepartment of Psychiatry, Washington University School of Medicine.
Norrina B AllenInstitute for Innovations in Developmental Sciences, Northwestern University.
Mallinckrodt (United States) · USStony Brook University · USUniversity of Utah · US

Funding

Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental DisordersR01MH113883 · NIMH · WASHINGTON UNIVERSITY · PI JOAN L. LUBY, Christopher Daniel Smyser · 2018 to 2026
$20.6M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Optimizing prediction of preschool psychopathology from brain: behavior markers of emotion dysregulation from birth: A computational, developmental cognitive neuroscience approachR01MH121877 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUBY, JOAN L., ROGERS, CYNTHIA ELISE · 2020 to 2024
$8.2M
Validation of Preschool Depressive SyndromeR01MH064769 · NIMH · WASHINGTON UNIVERSITY · PI LUBY, JOAN L. · 2003 to 2012
$7.7M
Generating an Earlier Science of When to Worry: A Neurodevelopmental, Transactional Approach to Characterizing Irritability Patterns Beginning in InfancyR01MH107652 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2016 to 2021
$4.0M
Dimensions of Early Temper Loss and Low Concern: Clinical Utility and MechanismsU01MH082830 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2014 to 2018
$3.9M
Developmental Characterization of Preschool Disruptive BehaviorR01MH082830 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2009 to 2013
$3.7M
Early Traumatic Stress Exposure: Neurodevelopmental Mechanisms of Clinical RiskU01MH090301 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BRIGGS-GOWAN, MARGARET J · 2012 to 2014
$2.4M
Early Traumatic Stress Exposure: Neurodevelopmental Mechanisms of Clinical RiskR01MH090301 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BRIGGS-GOWAN, MARGARET J · 2010 to 2011
$1.3M
NICHD NIH HHS P50 HD103525NIMH NIH HHS R01 MH064769NIMH NIH HHS R01 MH082830NIMH NIH HHS R01 MH090301NIMH NIH HHS R01 MH107652NIMH NIH HHS R01 MH113883NIMH NIH HHS R01 MH121877NIMH NIH HHS U01 MH082830NIMH NIH HHS U01 MH090301
6 · The paper itself

Abstract

objectiveWe provide proof-of-principle for a mental health risk calculator advancing clinical utility of the irritability construct for identification of young children at high risk for common, early onsetting syndromes.

methodData were harmonized from two longitudinal early childhood subsamples (total

resultsCompared to the base model, the addition of early childhood irritability and adverse childhood experiences significantly improved the AUC (0.765) and IDI slope (0.192). Overall, 23% of preschoolers went on to develop a preadolescent internalizing/externalizing disorder. For preschoolers with both elevated irritability and adverse childhood experiences, the likelihood of an internalizing/externalizing disorder was 39-66%.

conclusionsPredictive analytic tools enable personalized prediction of psychopathological risk for irritable young children, holding transformative potential for clinical translation.

Indexed as

Irritable MoodChildChild, PreschoolDepressionFemaleHumansLongitudinal StudiesMaleMental HealthProblem BehaviorRisk AssessmentRisk Factors

Identifiers

PMID36975800
PMCPMC10533737
OpenAlexW4361190805

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.