Evidence map›Paper›PMID 36975787›Full record

ArticleAntimicrobial agents and chemotherapy2023

Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections.

Tram Le, Sue C Nang, Jinxin Zhao, Heidi H Yu, Jian Li, Jason J Gill, Mei Liu, Saima Aslam

Open access · greenAbstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Bacteriophage Therapy AgainstMicroorganisms · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Phage therapy againstFrontiers in microbiology · 2026
    Review
  10. Phage and endolysin-based inhibition ofFrontiers in cellular and infection microbiology · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. [Potential of bacteriophage therapy in Germany: evidence and clinical relevance].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025
    Review
  19. Review
  20. State-of-the-Art Review: Recurrent Uncomplicated Urinary Tract Infections in Women.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tram Le *Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.
Sue C Nang *Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
Jinxin ZhaoBiomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
Heidi H YuBiomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
Jian LiBiomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0001-7953-8230
Jason J GillCenter for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.
Mei LiuCenter for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.
Saima AslamDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-4051-5629
Australian Regenerative Medicine Institute · AUTexas A&M University · USUniversity of California San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Organoid Cultivation CoreU19AI157981 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI LEMON, KATHERINE PAIGE · 2021 to 2025
$12.4M
Towards the Translation of Synergistic Phage-Polymyxin Combination Therapy against Pandrug-resistant Klebsiella pneumoniae: A Systems ApproachR21AI156766 · NIAID · MONASH UNIVERSITY · PI LI, JIAN · 2021 to 2022
$348k
NCATS NIH HHS UL1 TR001442NIAID NIH HHS R21 AI156766NIAID NIH HHS U19 AI157981
6 · The paper itself

Abstract

Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed. We describe a case of rUTI due to extended spectrum beta lactamase (ESBL) Klebsiella pneumoniae in a KTR that was treated successfully with 4 weeks of adjunctive intravenous bacteriophage therapy alone, without concomitant antibiotics, and with no recurrence in a year of follow-up.

Indexed as

beta-LactamasesUrinary Tract InfectionsAnti-Bacterial AgentsHumansKlebsiella pneumoniaeRetrospective StudiesAnti-Bacterial Agentsbeta-LactamasesbacteriophageESBLkidney transplantphagerUTI

Identifiers

PMID36975787
PMCPMC10112157
OpenAlexW4361191212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.