Evidence map›Paper›PMID 36975625›Full record

ArticleGels (Basel, Switzerland)2023

The Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections.

Beatriz Toirac, John Jairo Aguilera-Correa, Aranzazu Mediero, Jaime Esteban, Antonia Jiménez-Morales

Open access · goldFull text read
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Beatriz ToiracMaterials Science and Engineering and Chemical Engineering Department, Carlos III University of Madrid, 28911 Madrid, Spain.ORCID 0000-0002-1102-9947
John Jairo Aguilera-CorreaClinical Microbiology Department, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain.
Aranzazu MedieroBone and Joint Unit, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain.ORCID 0000-0002-5368-574X
Jaime EstebanClinical Microbiology Department, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain.ORCID 0000-0002-8971-3167
Antonia Jiménez-MoralesMaterials Science and Engineering and Chemical Engineering Department, Carlos III University of Madrid, 28911 Madrid, Spain.ORCID 0000-0002-9861-2309
Centro de Investigación Biomédica en Red · ESHospital Universitario Fundación Jiménez Díaz · ESUniversidad Carlos III de Madrid · ES

Funding

Regional Government of Madrid ADITIMAT (ref. P2018/NMT-4411)Regional Government of Madrid CIBERINFEC-CIBER of Infectious Diseases (CB21/13/00043)Spanish Ministry of Education, Culture, and Sports FPU grant (FPU17/05977)
6 · The paper itself

Abstract

Orthopedic prosthesis-related infections (OPRI) are an essential health concern. OPRI prevention is a priority and a preferred option over dealing with poor prognosis and high-cost treatments. Micron-thin sol-gel films have been noted for a continuous and effective local delivery system. This study aimed to perform a comprehensive in vitro evaluation of a novel hybrid organic-inorganic sol-gel coating developed from a mixture of organopolysiloxanes and organophosphite and loaded with different concentrations of linezolid and/or cefoxitin. The kinetics of degradation and antibiotics release from the coatings were measured. The inhibition of biofilm formation of the coatings against

Indexed as

cefoxitinElectrochemical Impedance SpectroscopyEscherichia colilinezolidnanogelsProsthesis-Related Infectionssol–gel coatingStaphylococcus aureusStaphylococcus epidermidis

Identifiers

PMID36975625
PMCPMC10048042
OpenAlexW4321787474

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read52
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.