Evidence map›Paper›PMID 36975457›Full record

ReviewCurrent oncology (Toronto, Ont.)2023

Primary Prophylaxis Lapelga

Fahad Khan, Morgan Black, Alaina Charlton, Jawaid Younus

Open access · goldFull text readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fahad KhanDepartment of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
Morgan BlackDepartment of Oncology, London Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada.ORCID 0000-0002-7087-7727
Alaina CharltonDepartment of Oncology, London Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Jawaid YounusDepartment of Oncology, London Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada.
London Health Sciences Centre · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLapelga

methodsAdult patients with early breast cancer treated with adjuvant chemotherapy at the London Regional Cancer Program in London, ON, Canada between May 2019 and June 2022 were included. All of these patients were supported with Lapelga

resultsA total of 201 patients were included in this review with majority (78%) of patients under 65 years of age. One third of patients were treated with the adriamycin and cyclophosphamide (AC)-Paclitaxel dose dense chemotherapy and a quarter of patients with either a docetaxel and cyclophosphamide (TC) combination or an AC-dose dense with Paclitaxel weekly, and 10% or less patients had FEC-D (5-fluorouracil, epirubicin, and cyclophosphamide) and AC chemotherapy. FN incidence was only 3.48% in this review (7/201 patients). Patients with FN were admitted to hospital and recovered completely with no mortality reported. No cases of a switch to a different granulocyte colony growth factor were seen. The most frequent side effects from Lapelga

conclusionsIn this single centre retrospective study, early breast cancer patients (n = 201) treated with adjuvant chemotherapy supported with primary prophylaxis with Lapelga

Indexed as

Biosimilar PharmaceuticalsBreast NeoplasmsAdultCyclophosphamideDoxorubicinFemaleGranulocyte Colony-Stimulating FactorHumansOntarioPaclitaxelRetrospective StudiesBiosimilar PharmaceuticalsCyclophosphamideDoxorubicinGranulocyte Colony-Stimulating FactorPaclitaxelbreast cancerfebrile neutropeniaLapelga®pegfilgrastim

Identifiers

PMID36975457
PMCPMC10047890
OpenAlexW4323845226

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read18
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.