Evidence map›Paper›PMID 36975368›Full record

ReviewAntibodies (Basel, Switzerland)2023

Cutaneous Lymphoma and Antibody-Directed Therapies.

Alvise Sernicola, Christian Ciolfi, Paola Miceli, Mauro Alaibac

Open access · goldFull text readReview
In one paragraph

Review in Antibodies (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alvise SernicolaDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.ORCID 0000-0002-1985-0326
Christian CiolfiDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.ORCID 0000-0002-9098-4124
Paola MiceliDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.
Mauro AlaibacDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The introduction of monoclonal antibodies such as rituximab to the treatment of cancer has greatly advanced the treatment scenario in onco-hematology. However, the response to these agents may be limited by insufficient efficacy or resistance. Antibody-drug conjugates are an attractive strategy to deliver payloads of toxicity or radiation with high selectivity toward malignant targets and limited unwanted effects. Primary cutaneous lymphomas are a heterogeneous group of disorders and a current area of unmet need in dermato-oncology due to the limited options available for advanced cases. This review briefly summarizes our current understanding of T and B cell lymphomagenesis, with a focus on recognized molecular alterations that may provide investigative therapeutic targets. The authors reviewed antibody-directed therapies investigated in the setting of lymphoma: this term includes a broad spectrum of approaches, from antibody-drug conjugates such as brentuximab vedotin, to bi-specific antibodies, antibody combinations, antibody-conjugated nanotherapeutics, radioimmunotherapy and, finally, photoimmunotherapy with specific antibody-photoadsorber conjugates, as an attractive strategy in development for the future management of cutaneous lymphoma.

Indexed as

antibody combinationsantibody–drug conjugatesbi-specific T cell engagerbrentuximab vedotincutaneous lymphomamonoclonal antibodiesnanobioconjugatesphotoimmunotherapyradioimmunotherapyrituximab

Identifiers

PMID36975368
PMCPMC10045448
OpenAlexW4323046100

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read31
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.