Evidence map›Paper›PMID 36975245›Full record

ArticleBehavioral sciences (Basel, Switzerland)2023

Short Report: Lack of Diurnal Variation in Salivary Cortisol Is Linked to Sleep Disturbances and Heightened Anxiety in Adolescents with Williams Syndrome.

Jessica Hayton, Atiqah Azhari, Gianluca Esposito, Ray Iles, Michaella Chadiarakos, Giulio Gabrieli, Dagmara Dimitriou, Stephen Mangar

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral sciences (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Jessica HaytonSleep Education and Research Laboratory, UCL Institute of Education, 25 Woburn Square, London WC1H 0AA, UK.ORCID 0000-0001-8123-0681
Atiqah AzhariPsychology Programme, School of Humanities and Behavioural Sciences, Singapore University of Social Sciences, Singapore 599494, Singapore.ORCID 0000-0002-8809-5635
Gianluca EspositoAffiliative Behaviour and Physiology Lab, Department of Psychology and Cognitive Science, University of Trento, 38068 Rovereto, Italy.ORCID 0000-0002-9442-0254
Ray IlesDepartment of Veterinary Medicine, University of Cambridge, Cambridge CB2 1TN, UK.ORCID 0000-0003-0573-9739
Michaella ChadiarakosSleep Education and Research Laboratory, UCL Institute of Education, 25 Woburn Square, London WC1H 0AA, UK.
Giulio GabrieliNeuroscience and Behaviour Laboratory, Italian Institute of Technology, 00161 Roma, Italy.ORCID 0000-0002-9846-5767
Dagmara DimitriouSleep Education and Research Laboratory, UCL Institute of Education, 25 Woburn Square, London WC1H 0AA, UK.ORCID 0000-0002-6856-0595
Stephen MangarDepartment of Clinical Oncology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK.ORCID 0000-0002-3655-2830
University College London · GBImperial College Healthcare NHS Trust · GBItalian Institute of Technology · ITSingapore University of Social Sciences · SGUniversity of Cambridge · GBUniversity of Trento · IT

Funding

Williams France N/A
6 · The paper itself

Abstract

objectiveThe aim of the current study was to examine the potential relationship between sleep patterns, cortisol levels, and anxiety profiles in adolescents with Williams Syndrome (WS) compared to typically developing adolescents.

methodThirteen adolescents with WS and thirteen TD adolescents (age range 12-18 years) were recruited. Participants were provided with a "testing kit", containing instructions for collecting data through a sleep diary, MotionWare actigraphy, the Childhood Sleep Habits Questionnaire (CSHQ), and the Spence Children's Anxiety Scale, and a salivary cortisol collection kit.

resultsAdolescents in the WS group did not show diurnal variation in salivary cortisol. Significantly higher scores were reported for two CSHQ subsections, night wakings and parasomnias, in the WS group. Regarding the actigraphy, only significantly longer sleep latency was observed in the WS group. In comparison to the TD group, the WS group had significantly higher anxiety. As expected, the TD group showed typical diurnal variation in cortisol, whereas the WS group showed a flattened cortisol profile throughout the day.

conclusionsFrom the developmental perspective, this study provides new data supporting the conclusion that sleep problems are not transient but continue to persist into adolescence in WS. Future studies ought to consider examining the role of cortisol and its interplay with anxiety levels and sleep problems across the lifespan in individuals with WS.

Indexed as

adolescentsanxietycortisolsleepWilliams Syndrome

Identifiers

PMID36975245
PMCPMC10045386
OpenAlexW4323043859

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.