Evidence map›Paper›PMID 36975176›Full record

ArticleACS applied materials & interfaces2023

Repurposing Anthelmintics: Rafoxanide- and Copper-Functionalized SBA-15 Carriers against Methicillin-Resistant

Maricely Ramírez-Hernández, Javiera Norambuena, Hongnan Hu, Belvin Thomas, Chaoyun Tang, Jeffrey M Boyd, Tewodros Asefa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Treatment ofAntimicrobial agents and chemotherapy · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maricely Ramírez-HernándezDepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States.
Javiera NorambuenaDepartment of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, 76 Lipman Drive, New Brunswick, New Jersey 08901, United States.
Hongnan HuDepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0003-3364-2475
Belvin ThomasDepartment of Chemistry and Chemical Biology Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, United States.
Chaoyun TangDepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States.
Jeffrey M BoydDepartment of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, 76 Lipman Drive, New Brunswick, New Jersey 08901, United States.ORCID 0000-0001-7721-3926
Tewodros AsefaDepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0001-8634-5437

Funding

Mechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.R01AI139100 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI BOYD, JEFF M · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI139100
6 · The paper itself

Abstract

The development of materials that can more efficiently administer antimicrobial agents in a controlled manner is urgently needed due to the rise in microbial resistance to traditional antibiotics. While new classes of antibiotics are developed and put into widespread usage, existing, inexpensive compounds can be repurposed to fight bacterial infections. Here, we present the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials with physisorbed rafoxanide (RFX), a commonly used salicylanilide anthelmintic, and anchored Cu(II) ions that exhibit enhanced antimicrobial efficacy against the pathogenic bacterium

Indexed as

AnthelminticsAnti-Infective AgentsMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsCopperMicrobial Sensitivity TestsRafoxanideSilicon DioxideStaphylococcus aureusAnthelminticsAnti-Bacterial AgentsAnti-Infective AgentsCopperRafoxanideSBA-15Silicon DioxideanthelminthicsantimicrobialcopperMRSArafoxanideSBA-15 nanomaterialsStaphylococcus aureus

Identifiers

PMID36975176
PMCPMC10257252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.