Evidence map›Paper›PMID 36975169›Full record

ArticleImmunology and cell biology2023

ChAdOx1 nCoV-19 vaccination generates spike-specific CD8

William S Foster, Joseph Newman, Nazia Thakur, Alexandra J Spencer, Sophie Davies, Danielle Woods, Leila Godfrey, Sarah H Ross, Hayley J Sharpe, Arianne C Richard and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

William S FosterLymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, UK.ORCID 0000-0002-7103-3657
Joseph NewmanThe Pirbright Institute, Pirbright, Woking, UK.
Nazia ThakurThe Pirbright Institute, Pirbright, Woking, UK.
Alexandra J SpencerLymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, UK.
Sophie DaviesThe Jenner Institute, University of Oxford, Oxford, UK.
Danielle WoodsOxford Vaccine Group, Medical Sciences Division, Department of Paediatrics, University of Oxford and Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Leila GodfreyThe Jenner Institute, University of Oxford, Oxford, UK.
Sarah H RossLymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, UK.
Hayley J SharpeSignalling Programme, Babraham Institute, Babraham Research Campus, Cambridge, UK.
Arianne C RichardLymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, UK.
Dalan BaileyThe Pirbright Institute, Pirbright, Woking, UK.
Teresa Lambe *The Jenner Institute, University of Oxford, Oxford, UK.
Michelle A Linterman *Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, UK.ORCID 0000-0001-6047-1996
Babraham Institute · GBUniversity of Oxford · GBThe Pirbright Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/B/000C0427Biotechnology and Biological Sciences Research Council BBS/E/B/000C0428Biotechnology and Biological Sciences Research Council BBS/E/B/000C0433Biotechnology and Biological Sciences Research Council BBS/E/I/00007031Biotechnology and Biological Sciences Research Council BBS/E/I/COV07001Biotechnology and Biological Sciences Research Council BB/T008784/1Medical Research Council MR/W005611/1Medical Research Council MR/W016303/1Wellcome TrustWellcome Trust 109407
6 · The paper itself

Abstract

Effective vaccines have reduced the morbidity and mortality caused by severe acute respiratory syndrome coronavirus-2 infection; however, the elderly remain the most at risk. Understanding how vaccines generate protective immunity and how these mechanisms change with age is key for informing future vaccine design. Cytotoxic CD8

Indexed as

CD8-Positive T-LymphocytesCOVID-19AnimalsAntibodies, ViralChAdOx1 nCoV-19HumansMiceT-Lymphocytes, CytotoxicVaccinationAntibodies, ViralChAdOx1 nCoV-19AgingCD8+ T cellsimmunitySARS-CoV-2vaccination

Identifiers

PMID36975169
PMCPMC10952561
OpenAlexW4361190443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.