Evidence map›Paper›PMID 36974988›Full record

Trial reportHuman vaccines & immunotherapeutics2023

Immunogenicity and safety of the non-typable

Ilaria Galgani, Airi Põder, Rain Jõgi, Veli-Jukka Anttila, Stefano Milleri, Alberto M Borobia, Odile Launay, Marco Testa, Daniela Casula, Luca Grassano and 3 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIEquivalence TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03894969 (Immunogenicity and Safety Study of GSK's Investigational Vaccine), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03894969 phase2completednot on this map

Immunogenicity and Safety Study of GSK's Investigational Vaccine (GSK3277511A) When Administered in Healthy Smokers and Ex-smokers Following Receipt of Shingrix Vaccine

TypeinterventionalSponsorGlaxoSmithKlineRan2019 to 2021Enrolled541ConditionsRespiratory DisordersArmsGSK's investigational non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) multi-antigen vaccine (GSK3277511A) adjuvanted with AS01E, Shingrix GSK's lyophilized formulation of the herpes zoster (HZ) vaccine (GSK1437173A)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy.Transplant infectious disease : an official journal of the Transplantation Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 7 countries.

Ilaria GalganiGSK, Siena, Italy.ORCID 0000-0001-6315-4259
Airi PõderThe Clinical Research Center, Tartu, Estonia.
Rain JõgiThe Lung Clinic, Tartu University Hospital, Tartu, Estonia.
Veli-Jukka AnttilaDepartment of Infectious Diseases, Inflammation Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
Stefano MilleriCentro Ricerche Cliniche di Verona Srl, Verona, Italy.
Alberto M BorobiaClinical Pharmacology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.
Odile LaunayUniversité Paris Cité, Paris, France.
Marco TestaGSK, Siena, Italy.
Daniela CasulaGSK, Siena, Italy.
Luca GrassanoGSK, Siena, Italy.
Annaelisa TasciottiGSK, Siena, Italy.
Marie DozotGSK, Rixensart, Belgium.
Ashwani K AroraGSK, Wavre, Belgium.
GlaxoSmithKline (Belgium) · BECenter for Clinical Research (United States) · USCouncil of Independent Colleges · USSpanish Clinical Research Network · ESTartu University Hospital · EEUniversity of Helsinki · FIUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A candidate AS01-adjuvanted vaccine containing four surface proteins from non-typable

Indexed as

Herpes ZosterHerpes Zoster VaccinePulmonary Disease, Chronic ObstructiveHaemophilus influenzaeHumansImmunogenicity, VaccineMoraxella catarrhalisVaccines, SyntheticHerpes Zoster VaccineVaccines, Syntheticadjuvant systemAS01chronic obstructive pulmonary diseaseimmune responseMoraxella catarrhalisnon-inferioritynon-typable Haemophilus influenzaerecombinant zoster vaccine

Identifiers

PMID36974988
PMCPMC10078133
OpenAlexW4361191153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.