Evidence map›Paper›PMID 36974529›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2023

Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Samaneh Mirzaei Dahka, Maryam Afsharfar, Shirin Tajaddod, Mohammad Hassan Sohouli, Soheila Shekari, Fatemeh Bakhshi Nafouti, Atiyeh Alizadeh, Hanieh Shafahi Kachaei, Khadijeh Abbasi, Golsa Khalatbari Mohseni and 3 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samaneh Mirzaei DahkaStudent Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
Maryam AfsharfarDepartment of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Shirin TajaddodDepartment of Nutrition, School of Public Health, International Campus, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Hassan SohouliDepartments of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soheila ShekariDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Fatemeh Bakhshi NafoutiStudent Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
Atiyeh AlizadehDepartment of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Hanieh Shafahi KachaeiStudent Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
Khadijeh AbbasiFood Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan, Iran.
Golsa Khalatbari MohseniDepartment of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Farkhondeh AlamiStudent Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Maryam GholamalizadehCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeid DoaeiReproductive Health Research Center, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiation dermatitis (RD) is a common side effect of radiotherapy in most breast cancer patients. Curcumin has recently attracted more attention for managing the side effects of breast cancer treatments. This review study aimed to investigate the effect of curcumin on the severity of radiation dermatitis in patients with breast cancer.   Methods: All eligible randomized controlled trials (RCTs) were collected by searching PubMed, Scopus, Cochrane, and Web of Science. The effect size was expressed as weighted mean difference (WMD) and 95% confidence interval (CI). Study heterogeneity was assessed through Q statistics and I-squared.

resultsFour RCTs with 882 patients were included in the final analysis. The results of the meta-analysis indicated that curcumin supplementation significantly reduced radiation dermatitis severity (RDS) score in the intervention group compared to the control group (WMD=-0.50; 95% CI -0.72 to -0.27, P <0.001). A significant heterogeneity was observed between the studies (I2 = 95.7%, P < 0.001).

conclusionBased on the results of the present study, curcumin has significant effects in reducing the severity of radiation dermatitis in breast cancer patients receiving radiotherapy. Further well-designed longitudinal studies are recommended to confirm these results and to discover the underlying mechanisms of the effects of curcumin on the severity of radiation dermatitis in patients with cancer.

Indexed as

Breast NeoplasmsCurcuminRadiodermatitisDietary SupplementsFemaleHumansRandomized Controlled Trials as TopicCurcuminbreast cancercurcumindermatitisRadiation

Identifiers

PMID36974529
PMCPMC10334089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.