Evidence map›Paper›PMID 36974340›Full record

ArticleCartilage2024

Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair.

Arya Amirhekmat, Wendy E Brown, Evelia Y Salinas, Jerry C Hu, Kyriacos A Athanasiou, Dean Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arya AmirhekmatSchool of Medicine, University of California, Irvine, Irvine, CA, USA.
Wendy E BrownDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-2546-7427
Evelia Y SalinasDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Jerry C HuDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0001-5387-8405
Dean WangSchool of Medicine, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-3005-1154
University of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFibrin sealants are routinely used for intra-articular surgical fixation of cartilage fragments and implants. However, the mechanical properties of fibrin sealants in the context of cartilage repair are unknown. The purpose of this study was to characterize the adhesive and frictional properties of fibrin sealants using an

designNative bovine cartilage-bone composites were assembled with a single application of Tisseel or Vistaseal. Composites were tested in tension and lap shear. In addition, the coefficient of friction (COF) was measured in a native cartilage annulus model alone and with minced cartilage. Finally, the effect of a double application of fibrin sealant was evaluated.

resultsThere were no significant differences in tensile modulus, ultimate tensile strength (UTS), shear modulus, or ultimate shear strength (USS) between the 2 fibrin sealants. Both fibrin sealants demonstrated a UTS and USS of <8 and <30 kPa, respectively. There were no differences in COF between the sealants when tested alone or with minced cartilage. A double application of fibrin sealant did not alter the mechanical properties compared with a single application of fibrin sealant.

conclusionsFibrin sealant adhesive properties are not affected by the sealant type studied or the number of applications in a bovine cartilage-bone model. Fibrin sealant tribological properties are not affected by sealant type or the addition of minced cartilage. The adhesive properties of Tisseel and Vistaseal were less than those desired for the

Indexed as

Cartilage, ArticularFibrin Tissue AdhesiveShear StrengthTensile StrengthTissue AdhesivesAnimalsBiomechanical PhenomenaCattleFrictionMaterials TestingFibrin Tissue AdhesiveTissue Adhesivescartilagefibrin gluefibrin sealantTisseelVistaseal

Identifiers

PMID36974340
PMCPMC11368899
OpenAlexW4361191091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.