Evidence map›Paper›PMID 36973819›Full record

ArticleVeterinary research2023

Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study.

Niels Vander Elst, Julie Bellemans, Jonas Steenbrugge, Chloë Geeroms, Koen Breyne, Sofie Piepers, Bruno Toledo-Silva, Fernando Nogueira de Souza, Freddy Haesebrouck, Sarne De Vliegher and 1 more

Open access · goldFull text read
In one paragraph

Article in Veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Non-Animals : an open access journal from MDPI · 2024
    Article
  7. Article
  8. Staphylococcal mastitis in dairy cows.Frontiers in veterinary science · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Niels Vander Elst *Laboratory of Biochemistry, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID http://orcid.org/0000-0001-6289-7288
Julie Bellemans *Laboratory of Biochemistry, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Jonas SteenbruggeLaboratory of Biochemistry, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Chloë GeeromsM-Team and Mastitis and Milk Quality Research Unit, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Koen BreyneMolecular Neurogenetics Unit, Neurology and Radiology Department, Massachusetts General Hospital-Harvard Medical School, 13th Street, Building 149, Charlestown, MA, 02129, USA.
Sofie PiepersM-Team and Mastitis and Milk Quality Research Unit, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Bruno Toledo-SilvaM-Team and Mastitis and Milk Quality Research Unit, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Fernando Nogueira de SouzaM-Team and Mastitis and Milk Quality Research Unit, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Freddy HaesebrouckDepartment of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Sarne De Vliegher *M-Team and Mastitis and Milk Quality Research Unit, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Evelyne Meyer *Laboratory of Biochemistry, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. Evelyne.Meyer@ugent.be.
Ghent University · BEHarvard University · USUniversidade de São Paulo · BR

Funding

Agentschap Innoveren en Ondernemen AIO.ONO.2014.0004Elanco Animal Health AIO.ONO.2014.0004
6 · The paper itself

Abstract

Streptococcus uberis is a major causative agent of bovine mastitis, an inflammation of the mammary gland with substantial economic consequences. To reduce antibiotic use in animal agriculture, alternative strategies to treat or prevent mastitis are being investigated. Bovine-associated non-aureus staphylococci are proposed in that respect due to their capacity to inhibit the in vitro growth of S. uberis. We demonstrate that priming the murine mammary gland with Staphylococcus chromogenes IM reduces S. uberis growth in comparison with non-primed glands. The innate immune system is activated by increasing IL-8 and LCN2, which may explain this decreased growth.

Indexed as

Cattle DiseasesMastitis, BovineStreptococcal InfectionsAnimalsCattleFemaleMammary Glands, AnimalMiceStaphylococcusStreptococcusbovine mastitisdairy cowNon-aureus staphylococciprimingStaphylococcus chromogenesStreptococcus uberis

Identifiers

PMID36973819
PMCPMC10044423
OpenAlexW4361002334

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read2
measurements read8
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.