Evidence map›Paper›PMID 36973764›Full record

ArticleJournal of nanobiotechnology2023

Exosome inspired photo-triggered gelation hydrogel composite on modulating immune pathogenesis for treating rheumatoid arthritis.

Ke Rui, Xiaoxuan Tang, Ziwei Shen, Chao Jiang, Qiugang Zhu, Shiyi Liu, Nan Che, Jie Tian, Jue Ling, Yumin Yang

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  18. Rheumatoid Arthritis Therapy Based on B Cells.Drug design, development and therapy · 2025
    Review
  19. Review
  20. Recent advances in injectable hydrogels for osteoarthritis treatments.Frontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ke Rui *Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Xiaoxuan Tang *Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Ministry of Education and Jiangsu Province, Nantong University, Nantong, China.
Ziwei Shen *Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Chao JiangInstitute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Qiugang ZhuDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Shiyi LiuDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Nan CheDepartment of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.
Jie TianInstitute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. tianjie@ujs.edu.cn.
Jue LingKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Ministry of Education and Jiangsu Province, Nantong University, Nantong, China. jl2016@ntu.edu.cn.
Yumin YangKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Ministry of Education and Jiangsu Province, Nantong University, Nantong, China. yangym@ntu.edu.cn.
Affiliated Hospital of Jiangsu University · CNJiangsu University · CNNantong University · CNNanjing Medical University · CN

Funding

National Natural Science Foundation of China 32230057National Natural Science Foundation of China 81971542, 82171771, 82171793Natural Science Foundation of Jiangsu Province BE2022766Natural Science Foundation of the Higher Education Institutions of Jiangsu Province 22KJA310003
6 · The paper itself

Abstract

Although exosome therapy has been recognized as a promising strategy in the treatment of rheumatoid arthritis (RA), sustained modulation on RA specific pathogenesis and desirable protective effects for attenuating joint destruction still remain challenges. Here, silk fibroin hydrogel encapsulated with olfactory ecto-mesenchymal stem cell-derived exosomes (Exos@SFMA) was photo-crosslinked in situ to yield long-lasting therapeutic effect on modulating the immune microenvironment in RA. This in situ hydrogel system exhibited flexible mechanical properties and excellent biocompatibility for protecting tissue surfaces in joint. Moreover, the promising PD-L1 expression was identified on the exosomes, which potently suppressed Tfh cell polarization via inhibiting the PI3K/AKT pathway. Importantly, Exos@SFMA effectively relieved synovial inflammation and joint destruction by significantly reducing T follicular helper (Tfh) cell response and further suppressing the differentiation of germinal center (GC) B cells into plasma cells. Taken together, this exosome enhanced silk fibroin hydrogel provides an effective strategy for the treatment of RA and other autoimmune diseases.

Indexed as

Arthritis, RheumatoidFibroinsHumansHydrogelsPhosphatidylinositol 3-KinasesT-Lymphocytes, Helper-InducerFibroinsHydrogelsPhosphatidylinositol 3-KinasesAutoimmune pathogenesisExosomesIn-situ hydrogelRheumatoid arthritisT follicular helper cells

Identifiers

PMID36973764
PMCPMC10044428
OpenAlexW4361217260

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read32
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.