Evidence map›Paper›PMID 36973743›Full record

ArticleTrials2023

Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study.

Karen J Bosma, Claudio M Martin, Karen E A Burns, Jordi Mancebo Cortes, Juan Carlos Suárez Montero, Yoanna Skrobik, Kevin E Thorpe, Andre Carlos Kajdacsy-Balla Amaral, Yaseen Arabi, John Basmaji and 21 more

Registry-linked trialOpen access · goldFull text readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02447692 (Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02447692 nacompletednot on this map

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2024Enrolled575ConditionsCritically Ill, Acute Respiratory FailureArmsPSV ventilation strategy, PAV+ ventilation strategy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 7 countries.

Karen J Bosma *Division of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada. KarenJ.Bosma@lhsc.on.ca.ORCID http://orcid.org/0000-0003-0423-7286
Claudio M Martin *Division of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Karen E A BurnsInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Jordi Mancebo CortesIntensive Care Department, Hospital Universitari Sant Pau, Barcelona, Spain.
Juan Carlos Suárez MonteroIntensive Care Department, Hospital Universitari Sant Pau, Barcelona, Spain.
Yoanna SkrobikDepartment of Medicine, McGill University, Québec, Canada.
Kevin E ThorpeDalla Lana School of Public Health, Biostatistics Division, University of Toronto, Toronto, ON, Canada.
Andre Carlos Kajdacsy-Balla AmaralInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Yaseen ArabiIntensive Care Department, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.
John BasmajiDivision of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Gaëtan BeduneauMedical Intensive Care Unit, Normandie Univ, UNIROUEN, EA 3830, Rouen University Hospital, 76000, Rouen, France.
Francois BeloncleMedical Intensive Care Department, Angers University Hospital, Angers, France.
Guillaume CarteauxService de Médecine Intensive Réanimation, Assistance Publique-Hôpitaux de Paris, CHU Henri Mondor-Albert Chenevier, Creteil, France.
Emmanuel CharbonneyCentre Hospitalier de l'Université de Montréal (CHUM) and Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.
Alexandre DemouleService de Médecine intensive - Réanimation Département, Hôpital Universitaire Pitié-Salpêtrière and Sorbonne Université Médecine, Paris, France.
Martin DresService de Médecine intensive - Réanimation Département, Hôpital Universitaire Pitié-Salpêtrière and Sorbonne Université Médecine, Paris, France.
Vito FanelliDepartment of Surgical Sciences, University of Turin, Turin, Italy.
Anna GeageaDivision of Critical Care Medicine, Department of Medicine, North York General Hospital, Toronto, ON, Canada.
Ewan GoligherInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
François LelloucheCentre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) - Université Laval, Québec City, QC, Canada.
Tommaso MaraffiIntensive Care Unit, Hôpital Intercommunal de Créteil, Créteil, France.
Alain MercatMedical Intensive Care Department, Angers University Hospital, Angers, France.
Pablo O RodriguezIntensive Care Unit, Instituto Universitario CEMIC (Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"), Av. Cnel. Diaz 2423 3rd floor, Buenos Aires, Argentina.
Jason ShahinDepartment of Critical Care, Division of Pulmonary Medicine, McGill University, Québec, Canada.
Stephanie SibleyDepartment of Emergency Medicine and Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.
Savino SpadaroDepartment of Translational Medicine, Faculty of Medicine and Surgery, University of Ferrara, Ferrara, Italy.
Katerina VaporidiUniversity Hospital of Heraklion, Voutes, Heraklion, Greece.
M Elizabeth WilcoxInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Laurent BrochardInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Canadian Critical Care Trials Group and
REVA Network
St. Michael's Hospital · CAWestern University · CAHospital de Sant Pau · ESMcGill University · CASorbonne Université · FRUniversité d'Angers · FRAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITCentre Hospitalier Universitaire Henri-Mondor · FRCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno · ARHôpital du Sacré-Cœur de Montréal · CAHôpital Intercommunal de Créteil · FRInstitut universitaire de cardiologie et de pneumologie de Québec · CAKing Abdulaziz Medical City · SANormandie Université · FRNorth York General Hospital · CAQueen's University · CASunnybrook Health Science Centre · CAUniversity Health Network · CAUniversity Hospital of Heraklion · GRUniversity of Ferrara · IT

Funding

CIHR IPR - 136755CIHR PJT - 162086
6 · The paper itself

Abstract

backgroundProportional assist ventilation with load-adjustable gain factors (PAV+) is a mechanical ventilation mode that delivers assistance to breathe in proportion to the patient's effort. The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient's respiratory effort or workload within a normal range. Short-term and physiological benefits of this mode compared to pressure support ventilation (PSV) include better patient-ventilator synchrony and a more physiological response to changes in ventilatory demand.

methodsThe objective of this multi-centre randomized controlled trial (RCT) is to determine if, for patients with acute respiratory failure, ventilation with PAV+ will result in a shorter time to successful extubation than with PSV. This multi-centre open-label clinical trial plans to involve approximately 20 sites in several continents. Once eligibility is determined, patients must tolerate a short-term PSV trial and either (1) not meet general weaning criteria or (2) fail a 2-min Zero Continuous Positive Airway Pressure (CPAP) Trial using the rapid shallow breathing index, or (3) fail a spontaneous breathing trial (SBT), in this sequence. Then, participants in this study will be randomized to either PSV or PAV+ in a 1:1 ratio. PAV+ will be set according to a target of muscular pressure. The weaning process will be identical in the two arms. Time to liberation will be the primary outcome; ventilator-free days and other outcomes will be measured. DISCUSSION: Meta-analyses comparing PAV+ to PSV suggest PAV+ may benefit patients and decrease healthcare costs but no powered study to date has targeted the difficult to wean patient population most likely to benefit from the intervention, or used consistent timing for the implementation of PAV+. Our enrolment strategy, primary outcome measure, and liberation approaches may be useful for studying mechanical ventilation and weaning and can offer important results for patients.

trial registrationClinicalTrials.gov NCT02447692 . Prospectively registered on May 19, 2015.

Indexed as

Interactive Ventilatory SupportRespiration, ArtificialHumansMulticenter Studies as TopicPositive-Pressure RespirationRandomized Controlled Trials as TopicRespirationVentilator WeaningPatient-ventilatory synchronyProportional assist ventilationVentilator-free daysWeaning from mechanical ventilationWork of breathing

Identifiers

PMID36973743
PMCPMC10041480
OpenAlexW4361301739

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read25
reference markers read2
identifiers read4
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.