Evidence map›Paper›PMID 36973730›Full record

ReviewDiabetology & metabolic syndrome2023

Metabolic health and adiposity transitions and risks of type 2 diabetes and cardiovascular diseases: a systematic review and meta-analysis.

Xuhui Zhang, Jinghan Zhu, Jean H Kim, Timothy S Sumerlin, Qi Feng, Jiazhou Yu

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Xuhui Zhang *Hangzhou Center for Disease Control and Prevention, Hangzhou, China.
Jinghan Zhu *The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Jean H KimJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
Timothy S SumerlinJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
Qi FengNuffield Department of Population Health, University of Oxford, Oxford, UK. Qi.Feng@ndph.ox.ac.uk.
Jiazhou YuJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Sha Tin, Hong Kong. jiazhouyu@cuhk.edu.hk.
Hong Kong Jockey Club · CNChinese University of Hong Kong · CNHangzhou Center for Disease Control and Prevention · CNSouthern Medical University · CNUniversity of Oxford · GB

Funding

Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang 2019R01007Zhoushan Public Welfare Science and Technology Projects 2020C31082
6 · The paper itself

Abstract

backgroundMetabolic health status and levels of adiposity are prone to change over time. Mixed results have been reported regarding the extent by which changes in metabolic health and weight affect cardiometabolic risks. This systematic review and meta-analysis aims to examine the association between transitions in metabolic health and adiposity status on risk of incident type 2 diabetes (T2DM) and cardiovascular disease (CVD) events.

methodsA systematic literature search was conducted on MEDLINE and EMBASE through August 2022 for prospective cohort studies examining transitions in metabolic health and adiposity status and risk of incident T2DM and CVDs without restrictions on language or publication status. Meta-analysis was performed to summarize hazard ratios for T2DM and composite CVD events separately using random-effects model.

resultsA total of 17 studies were included. Compared to stable metabolically healthy status, transition to metabolically unhealthy status significantly increased the risk of incident T2DM and composite CVD events among individuals with normal weight and individuals with overweight/obesity. Compared to stable metabolically unhealthy status, transition to metabolically healthy status significantly lowered the risk among individuals with normal weight and individuals with overweight/obesity. When metabolic health status remained unchanged, progression from normal weight to overweight/obesity significantly increased risk of CVDs but not risk of T2DM.

conclusionThe impact of change in metabolic health on the risks of T2DM and CVD is more prominent than that of change to body mass index category. Obesity treatment should consider prioritizing improvement in metabolic health parameters over focusing on the extent of weight loss only.

Indexed as

Cardiovascular diseaseMeta-analysisMetabolic healthObesityTransitionType 2 diabetes

Identifiers

PMID36973730
PMCPMC10045173
OpenAlexW4361223570

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read59
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.