ArticleNature neuroscience2023
Intrinsic activity development unfolds along a sensorimotor-association cortical axis in youth.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06701240 (Examining Effects of a Strengths-based Community-grounded Intervention for Parents and Their Young Children), which is not on this map. Cited by 131 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining Effects of a Strengths-based Community-grounded Intervention for Parents and Their Young Children
Who cites it
131 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Aperiodic and Hurst EEG exponents across early human brain development: A systematic review.Developmental cognitive neuroscience · 2024Pooled it
- Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Different functional connectivity gradients reflect aging and Alzheimer's disease.Nature neuroscience · 2026Article
- Cortical microarchitecture supports preadolescent functional brain network connectivity.bioRxiv : the preprint server for biology · 2026Article
- Intrinsic timescale develops hierarchically from sensorimotor to association cortex in youth and stabilizes in adulthood.PLoS biology · 2026Article
- State-dependent signal flow hierarchy in the human cerebral cortex.Nature neuroscience · 2026Article
- Cascading Periods of Language-Related Brain Plasticity Across Early Childhood.Developmental science · 2026Article
- Spatiotemporal white-matter development across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Developmental deviations of association-network structural connectivity in youths with ADHD predict symptom and treatment outcomes.Nature biomedical engineering · 2026Article
- Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion.Developmental cognitive neuroscience · 2026Article
- Article
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- Mapping Neuroanatomical Heterogeneity of Brain Aging Within a Clinically Defined Aging Reference Cohort.Bioengineering (Basel, Switzerland) · 2026Article
- Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth.Developmental cognitive neuroscience · 2026Article
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction.iScience · 2026Article
- Longitudinal Study of Adolescent Brain Connectivity Development Using Sign-Aware Graph Theory Metrics.Human brain mapping · 2026Article
- Convergent and divergent brain-cognition development in early adolescence.Nature communications · 2026Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
Animal studies of neurodevelopment have shown that recordings of intrinsic cortical activity evolve from synchronized and high amplitude to sparse and low amplitude as plasticity declines and the cortex matures. Leveraging resting-state functional MRI (fMRI) data from 1,033 youths (ages 8-23 years), we find that this stereotyped refinement of intrinsic activity occurs during human development and provides evidence for a cortical gradient of neurodevelopmental change. Declines in the amplitude of intrinsic fMRI activity were initiated heterochronously across regions and were coupled to the maturation of intracortical myelin, a developmental plasticity regulator. Spatiotemporal variability in regional developmental trajectories was organized along a hierarchical, sensorimotor-association cortical axis from ages 8 to 18. The sensorimotor-association axis furthermore captured variation in associations between youths' neighborhood environments and intrinsic fMRI activity; associations suggest that the effects of environmental disadvantage on the maturing brain diverge most across this axis during midadolescence. These results uncover a hierarchical neurodevelopmental axis and offer insight into the progression of cortical plasticity in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.