ArticleNature neuroscience2023
The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Simultaneous in vivo imaging of CaThe journal of physiological sciences : JPS · 2026Article
- Natural auditory behaviors invoke cognitive brain networks.Current opinion in neurobiology · 2026Review
- Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Spontaneous and stimulus-driven arousal produce distinct acetylcholine dynamics across sensory and prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- A shared predictive architecture in the sensory cortex for statistical and reward-based learning.Current opinion in neurobiology · 2026Review
- A non-canonical cholinergic pathway from the dorsal tail of the striatum to the auditory cortex.Nature communications · 2026Article
- Fast and accessible morphology-free functional fluorescence imaging analysis.PLoS computational biology · 2026Article
- Survey of Hippocampal Responses to Sound in Naive Mice Reveals Widespread Activation by Broadband Noise Onsets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Glutamatergic projection neurons in the basal forebrain underlie learned olfactory associational valence assignments.Nature communications · 2026Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Cholinergic Dynamics in the Septo-hippocampal System Provide Phasic Multiplexed Signals for Spatial Novelty and Correlate with Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain.Nature communications · 2025Article
- Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.Neuron · 2025Article
- Article
- A disinhibitory microcircuit in the temporal association cortex for fear retrieval to pure tones.Scientific reports · 2025Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.bioRxiv : the preprint server for biology · 2025Article
- Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes.Science advances · 2025Article
- Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cholinergic basal forebrain (CBF) signaling exhibits multiple timescales of activity with classic slow signals related to brain and behavioral states and fast, phasic signals reflecting behavioral events, including movement, reinforcement and sensory-evoked responses. However, it remains unknown whether sensory cholinergic signals target the sensory cortex and how they relate to local functional topography. Here we used simultaneous two-channel, two-photon imaging of CBF axons and auditory cortical neurons to reveal that CBF axons send a robust, nonhabituating and stimulus-specific sensory signal to the auditory cortex. Individual axon segments exhibited heterogeneous but stable tuning to auditory stimuli allowing stimulus identity to be decoded from population activity. However, CBF axons displayed no tonotopy and their frequency tuning was uncoupled from that of nearby cortical neurons. Chemogenetic suppression revealed the auditory thalamus as a major source of auditory information to the CBF. Finally, slow fluctuations in cholinergic activity modulated the fast, sensory-evoked signals in the same axons, suggesting that a multiplexed combination of fast and slow signals is projected from the CBF to the auditory cortex. Taken together, our work demonstrates a noncanonical function of the CBF as a parallel channel for state-dependent sensory signaling to the sensory cortex that provides repeated representations of a broad range of sound stimuli at all points on the tonotopic map.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.