Evidence map›Paper›PMID 36973385›Full record

ArticleScientific reports2023

Investigating TSPO levels in occupation-related posttraumatic stress disorder.

Sarah E Watling, Talwinder Gill, Erin V Gaudette, J Don Richardson, Tina McCluskey, Junchao Tong, Jeffrey H Meyer, Jerry Warsh, Rakesh Jetly, Michael G Hutchison and 4 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Sarah E WatlingInstitute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Talwinder GillInstitute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Erin V GaudetteInstitute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
J Don RichardsonThe MacDonald Franklin OSI Research Centre, Lawson Health Research Institute, London, ON, Canada.
Tina McCluskeyBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Junchao TongBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Jeffrey H MeyerInstitute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Jerry WarshInstitute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Rakesh JetlyDirectorate of Mental Health, Canadian Forces Health Services, Ottawa, ON, Canada.
Michael G HutchisonFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Shawn G RhindFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Sylvain HouleBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Stephen J KishInstitute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Isabelle BoileauInstitute of Medical Sciences, University of Toronto, Toronto, ON, Canada. isabelle.boileau@camh.ca.
University of Toronto · CACentre for Addiction and Mental Health · CACanadian Armed Forces · CASt Joseph's Health Care · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely understood. We tested the hypothesis that microglia activation, in fronto-limbic brain regions involved in PTSD, would be elevated in participants with occupation-related PTSD. We also explored the relationship between cortisol and microglia activation. Twenty participants with PTSD and 23 healthy controls (HC) completed positron emission tomography (PET) scanning of the 18-kDa translocator protein (TSPO), a putative biomarker of microglia activation using the probe [

Indexed as

Stress Disorders, Post-TraumaticAnxiety DisordersBrainChild, PreschoolHumansHydrocortisoneMaleOccupationsPositron-Emission TomographyReceptors, GABAHydrocortisoneReceptors, GABATSPO protein, human

Identifiers

PMID36973385
PMCPMC10041517
OpenAlexW4361003629

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read46
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.