Evidence map›Paper›PMID 36973291›Full record

ArticleNature communications2023

Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions.

Keisuke Nakamura, Ryou Kubota, Takuma Aoyama, Kenji Urayama, Itaru Hamachi

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In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Interspecies interactions in dual, fibrous gels enable control of gel structure and rheology.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keisuke NakamuraDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-0588-9374
Ryou KubotaDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan. rkubota@sbchem.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0001-8112-8169
Takuma AoyamaDepartment of Macromolecular Science and Engineering, Kyoto Institute of Technology, Kyoto, Japan.
Kenji UrayamaDepartment of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Itaru HamachiDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan. ihamachi@sbchem.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-3327-3916

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP17H06348MEXT | JST | Exploratory Research for Advanced Technology (ERATO) JPMJER1802
6 · The paper itself

Abstract

Synthetic composite hydrogels comprising supramolecular fibers and covalent polymers have attracted considerable attention because their properties are similar to biological connective tissues. However, an in-depth analysis of the network structures has not been performed. In this study, we discovered the composite network can be categorized into four distinct patterns regarding morphology and colocalization of the components using in situ, real-time confocal imaging. Time-lapse imaging of the network formation process reveals that the patterns are governed by two factors, the order of the network formation and the interactions between the two different fibers. Additionally, the imaging studies revealed a unique composite hydrogel undergoing dynamic network remodeling on the scale of a hundred micrometers to more than one millimeter. Such dynamic properties allow for fracture-induced artificial patterning of a network three dimensionally. This study introduces a valuable guideline to the design of hierarchical composite soft materials.

Identifiers

PMID36973291
PMCPMC10042874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.